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The lymphatic system absorbs excess fluid from tissues, returns it to the circulatory system, and plays an additional role in immunity. It is composed of lymph, lymphatic tissue including lymph nodes and spleen, and lymphatic vessels. Lymph nodes filter lymph for infectious particles. The lymphatic system relies on rhythmic vessel contractions and skeletal muscle movement to transport lymph since it lacks a pump. It also generates immune cells through the bone marrow and thymus. Inflammation is the body's response to tissue damage or infection, characterized by redness, swelling, heat and pain, and functions to remove pathogens and debris and initiate tissue repair through chemical messengers and leukocyte deployment.
The lymphatic system absorbs excess fluid from tissues, returns it to the circulatory system, and plays an additional role in immunity. It is composed of lymph, lymphatic tissue including lymph nodes and spleen, and lymphatic vessels. Lymph nodes filter lymph for infectious particles. The lymphatic system relies on rhythmic vessel contractions and skeletal muscle movement to transport lymph since it lacks a pump. It also generates immune cells through the bone marrow and thymus. Inflammation is the body's response to tissue damage or infection, characterized by redness, swelling, heat and pain, and functions to remove pathogens and debris and initiate tissue repair through chemical messengers and leukocyte deployment.
The lymphatic system absorbs excess fluid from tissues, returns it to the circulatory system, and plays an additional role in immunity. It is composed of lymph, lymphatic tissue including lymph nodes and spleen, and lymphatic vessels. Lymph nodes filter lymph for infectious particles. The lymphatic system relies on rhythmic vessel contractions and skeletal muscle movement to transport lymph since it lacks a pump. It also generates immune cells through the bone marrow and thymus. Inflammation is the body's response to tissue damage or infection, characterized by redness, swelling, heat and pain, and functions to remove pathogens and debris and initiate tissue repair through chemical messengers and leukocyte deployment.
Returns this fluid to the circulatory system or the heart
Additional function in Immunity Components of the Lymphatic System Lymph Lymphatic Tissue Lymphatic Vessels Thymus Bone Marrow Spleen Lymph Lymph The clear fluid absorbed by the lymphatic system Lymphatic Tissue Clusters of Lymphocytes and macrophages Lymphatic Tissue Malt: (Mucosa Associated Lymphatic Tissue) Diffuse array of lymphocytes found along body passages in mucous membranes. Examples of malt: lining of the stomach and respiratory tract Lymph nodules: Dense clusters of Lymphocytes Transient: pop up during infection Lymphatic Vessels Carry and Transport Lymph and proteins
Similar Structure to veins Tunica Interna: Thin inner lining and valves Tunica Media: Elastic fibers and Smooth Muscle Tunica Externa: Thin Outer Layer
Lymphatic Filters Lymph Nodes- Screen and Filter Lymph for infectious particles
Spleen- Screen and Filter Blood for old, dead cells and infectious particles
Subclavian
2 collecting Trunks
6 Lymphatic Trunks
More Collecting Vessels
Lymph Nodes
Collecting Vessels
Lymphatic Vessels Lymphatic Movement No pump
Rhythmic contraction of the lymph vessels
Skeletal Muscles
How is backflow prevented? Immune Cell Generators Bone Marrow- Makes B- Cells
Thymus- Makes T- Cells Thymus Break for Dynamic Human Inflammation
Non-specific response to tissue trauma or infection
4 signs of Inflammation Redness Swelling Heat Pain
Whats the purpose of pain? Purpose of Inflammation Remove Invading Pathogens
Remove Debris of Damaged Tissues
Initiate Tissue Repair
Mediators of Inflammation Chemical Messengers
Leukocyte Chemical Messengers Released by mast cells in response to damage
Bradykinin, Histamine, and Leukotrienes Increases Local Blood Flow to distressed area Stimulates Vasodilation Increases Permeability of Capillaries
Whats Accomplished? Chemical Messengers Bradykinin, Histamine, and Leukotrienes Increases Local Blood Flow Stimulates Vasodilation Increases Permeability of Capillaries Whats Accomplished? Heats area causes redness and swelling Dilutes toxins and helps Remove waste Supplies oxygen and nutrients for tissue repair Pain Response Purpose?
Causes?
Pain Response Purpose? Prevents further injury to area.
Causes? Direct Nerve Damage Pressure from Swelling Chemical Stimulation particularly bradykinin Leukocyte Deployment Leukocyte: any white blood cell including T cells, B cells, granulocytes, platelets, basophils, mast cells, monocytes and macrophages
Leukocytes Migrate toward inflammed area
Why? TO KILL and RECRUIT Leukocyte Deployment Leukocytes Migrate to inflammed tissue
How? 1. Margination or pavementing: To migrate to the wall of a capillary 2. Diapedesis: Passage of blood cells through vessel wall into tissue 3. Chemotaxis: Movement of a cell towards or away a chemical source What do the leukocytes plan to do?
Phagocytosis: release of toxic chemicals
Recruit more leukocytes
Phagocytosis Leukocytes consume and destroy foreign invaders and dead cells
Ejected as Pus Break for Dynamic Human Selected Topics in Immunity