Gu5095.

1
Terry Wood

Pfizer Global Research & Development
Sandwich, UK
An Automated Approach
to the Supply of Samples
for Screening
Gu5095.2
Automated
Liquid
Sample
Bank
A secure store
for >2.5 million
samples capable
of delivering
daughter plates
on demand
Gu5095.3
Project Plan
The System
Deliverables
Future
Gu5095.4
The Numbers Challenge
0
n
2n
3n
4n
5n
6n
Year
Compounds
Tested

1997 1998 1999 2000 2001 2002 2003 2004 2005
Gu5095.5
best return on
investment
stability
less time per hit
Faster
Gu5095.6
Return on Investment
Aggregated
Cost
($ millions)
Year
0
1997 1998 1999 2000 2001 2002 2003 2004 2005
2
4
6
8
10
12
14
ALSB
Manual
+ staff increase
16
0
Gu5095.7
FAT - Factory Acceptance Test
Milestones
PINT - Pfizer Integration
SAT - Site Acceptance Test
Gu5095.8
Factory Acceptance Test
Gu5095.9
FAT - Factory Acceptance Test
Milestones
SAT - Site Acceptance Test
PINT - Pfizer Integration
Gu5095.10
Site Acceptance Test
Administrator Form Operation Functionality of all GUI forms that allow the
administrator to set orders.
Administrator Transactions Testing of all sample withdrawal, replacement
and replenishment capabilities described in the
specification.
Daughter Plate Orders Ensure the system delivers all permissible
variations of daughter plate format.
Access Procedures The various elements within the ALSB must be
accessible, but only when the system is in a safe
condition.
Replenishment of Consumable Items Demonstration that all consumable storage
modules are accessible, operable and give
suitable alerts when running low.
Alarm Conditions and Recovery from Failure Simulation of a wide range of hardware, software
and service failures, to demonstrate that the
equipment fails safe and the system is
recoverable.
Performance Testing Does the system delivers its output within the
time frames specified.

Administrator Form Operation Functionality of all GUI forms that allow the administrator to set
orders.

Administrator Transactions Testing of all sample withdrawal, replacement and replenishment
capabilities described in the specification.

Daughter Plate Orders Ensure the system delivers all permissible variations of daughter
plate format.

Access Procedures The various elements within the ALSB must be accessible, but only
when the system is in a safe condition.

Replenishment of Demonstration that all consumable storage modules are accessible,
Consumable Items operable and give suitable alerts when running low.

Alarms and Recovery Simulation of a wide range of hardware, software and service from
Failure failures, to demonstrate that the equipment fails safe and the system
is recoverable.

Performance Testing Does the system delivers its output within the time frames specified.
Gu5095.11
FAT - Factory Acceptance Test
Milestones
SAT - Site Acceptance Test
PINT - Pfizer Integration
Gu5095.12
Pfizer Integration Testing
Gu5095.13
Legacy Sample Transfer
Plate Based Tube Based
+ Tube I.d.
+ Tube Septum
+ Volume
Gu5095.14
Cold Store
Defrost Station
Conveyor System
Liquid
Handling
Cells
The Technical Solution
Customers
600 plates/24hrs

OR

6000 single/24hrs
Robot arm
Robotic Carousel
Key
Robotic Sample
Processor
up to 1000+
assay plates/24hrs
Gu5095.15
Cold
Store
Gantry
Robotics
Gu5095.16
Defrost Oven Feeder Robot
Gu5095.17
Liquid Handling Cell
Gu5095.18
Then ...
Gu5095.19
.. Now
Gu5095.20
Lessons Learnt
Marketing
Buy - in
Enhancements
2
o
not 1
o

Project buy-in
Cold Store Cold Store Extension
Defrost Station
Conveyor System
Conveyor System Extension
Advanced
RSPs
Future development
Total Automation System
Customers
Liquid
Handling
Cells
Gu5095.23