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BMED3510A
Luis Fonseca
llfonseca@gatech.edu
BMED3510 Section A
TA:
William A Shockey
ashockey@gatech.edu
Office hours: TBD
Format:
Summary
Functions
Derivatives
Notion of approximation (Taylor series)
ODEs
Numerical solution of an ODE
Boundedness
Unbounded
function
Bounded
function
Range
X
Domain
Extrema
Y
Global
maximum
Local
maxima
Local
minima
Global
minimum
Asymptotic behavior
Y
Linear Function
Power Functions
http://www.biology.arizona.edu/biomath/tutorials/power/GraphingPowerFunctions.html
http://www.biology.arizona.edu/biomath/tutorials/power/GraphingPowerFunctions.html
Trigonometric functions
Derivative of a function
lim
f a h f a
h 0
We write:
f x lim
The derivative of
f x h f x
h 0
f at a .
with respect to
x is
Differentiability
CORNERS
CUSPS
DISCONTINUITIES
VERTICAL TANGENTS
Example
= lim
()
3 + (3)
= 2 21 + 0 = 2 = 6
= lim
0
(3 + )2 +4 32 4
= lim
0
9 + 6 + 2 9
= lim
0
= lim (6 + ) 6
0
Differentiation shortcuts
d
f g x f g x g x
Chain Rule:
dx
Approximations
Why do we need approximations?
Chemical master equation
Mass action kinetics
Michaelis-Menten rate law
Newtons law
Concerns:
Accuracy
Range
Taylor series
x a
x a
x a
x a
f x f a f ' a
f ' ' a
f ' ' ' a
f ' ' ' ' a
.....
1!
2!
3!
4!
http://en.wikipedia.org/wiki/Taylor_series
x a
x a
x a
x a
f x f a f ' a
f ' ' a
f ' ' ' a
f ' ' ' ' a
.....
1!
2!
3!
4!
Solving ODEs
Analytical solutions
Example of X=aX
dX
aX
dt
dX
a dt ....
X
Chemical reactions
Electrostatics
Biology
Toxicology
Radioactivity
Luminescence
Numerical solutions
= (, )
Euler method
Y
+1 = + ( , )
Initial condition
(0 , 0 )
First solution
Second solution
Solving ODEs
Questions