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CYANIDE
POISONING
overview
Cyanide is traditionally known as
a poison and has been used in
mass homicides, in suicides, and
as a weapon of war.
The annual report of the
National Poison Data System of
the American Association of
Poison Control Centers
documented 247 reported cases
of chemical exposures to cyanide
in the United States in 2007.
Etiology of Cyanide
Poisoning
Pathophysiology of Acute
Cyanide Poisoning
Cyanide is highly lethal because it diffuses
into tissues and binds to target sites within
seconds
Intravenous and inhaled exposures produce
more rapid onset of signs and symptoms
than does oral or transdermal ingestion
The primary mechanism of cyanide
excretion is formation of thiocyanate within
the liver. Rhodanese catalyzes the
conversion of cyanide to thiocyanate, and
thiocyanate is then excreted via the kidneys.
Clinical Manifestations
The onset of signs and symptoms is
usually less than 1 minute after
inhalation and within a few minutes
after ingestion
diagnose
Anamnesis
Physical examination
Laboratorium examination
Differensial diagnosis
Carbonmonoxide intoxication
Management
Terima
kasih