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Agents
Antipsychotic Agents
Antipsychotic drugs are a class of
medicines used to treat psychosis
and other mental and emotional
conditions.
Psychosis is defined as "a serious mental disorder
(as schizophrenia) characterized by defective or
lost contact with reality often with hallucinations
or delusions.
Antipsychotic Agents
Also known as neuroleptics or major
tranquilizers
Neuroleptic: A term that refers to the effects
of antipsychotic drugs on a patient, especially
on his or her cognition and behavior.
The word neuroleptic originates from the Greek word
neuron ("nerve") and lepsis (a taking
hold)
Antipsychotic Agents
Antipsychotic medications are
generally divided into two
categories:
a. First generation (typical)
b. Second generation (atypical)
Antipsychotic Agents
Main difference between the
two types of antipsychotics :
a. First generation drugs block
dopamine
Antipsychotic Agents
Typical Antipsychotics
drugs
SUBCLASS
a. Phenothiazines
b. Thioxanthene
c. Butyrophenone
Phenothiazines
Three subfamilies of phenothiazines, based
primarily on the side chain of the molecule,
were once the most widely used of the
antipsychotic agents.
Thioxanthene
Thioxanthene is a chemical
compound in which the oxygen atom
in xanthene is replaced with a sulfur
atom
Drug: Thiothixene
Butyrophenone
More potent and to have fewer
autonomic effects but greater
extrapyramidal effects than
phenothiazines
Antipsychotic Agents
a.
b.
c.
d.
e.
f.
Dibenzodiazepine
Any of a class of antipsychotic drugs
having a structure based on a diazepine
heterocycle fused to two benzene rings
The dibenzodiazepine derivative is a socalled atypical or second-generation
antipsychotic that is widely regarded as
one of the most effective drug
treatments for schizophrenia and
depression
Drug: Clozapine
Benzisoxazole
Benzisoxazole is an aromatic
organic compound with a
molecular formula C7H5NO
containing a benzene-fused
isoxazole ring structure
Drug: Risperidone
Thienobenzodiazepine
A thienobenzodiazepine is a
heterocyclic compound containing a
diazepine ring fused to a thiophene
ring and a benzene ring.
Thienobenzodiazepines seem to act
relatively selectively at the alpha-2
subunit of the GABA-A receptor.
Drug: Olanzapine
Dibenzothiazepine
Dibenzothiazepines are chemical
compounds which are derivatives
of thiazepine with two benzene
rings.
Drug: Quetiapine
Dihydroindolone
A compound with an indole nucleus
similar to that of serotonin.
Drug: Ziprasidone
Dihydrocarbostyril
Drug: Aripiprazole