Академический Документы
Профессиональный Документы
Культура Документы
Complement
Ex. Extremely painActivate the
C3 Complement via alternative
pathwaysC3a and others
anaphylatoxinreceptor on
capillary endothelialvasodilatation,
increase permeabilitymassive
leakage of the plasmashock..
(anaphylactic shock)
Antibody
Ex.Antibody ( mostly IgG) produced
inside human body against self
antigen, due to similarity structure
to the intruder agent (ex.
Streptococcus Beta Haemolyticus
group A)Antibody attach to related
Ag activate complement
InflammationTissue injuryEx.
Rheumatic Heart Disease
Cytokines
Mostly activated by biological
product from outside human
body.
Ex. Proinflammatory citokines
(Interleukin 1 and TNF alpha) in
Avian influezae
infection.Massive destruction
of both side of human lung
Bacterial Product
Bacterial Product that Penetrate the
host Defence:
Capsule
Component of Cells Wall
Enzymes
Enzymes
1.
2.
3.
4.
5.
6.
7.
8.
9.
Leukocidins.
Hemolysin
Streptolysin
Coagulase.
Bacterial Kinase.
Hyalorunidase.
Collagenase.
Lecithinase.
Siderophore.
c. Diphtheriae
d. Erythrogenic
CPE.
Inclusion Body.
Syncitia or Giant Cells.
Interferon.
Bacterial capsules
Some bacteria produced strong
capsule consist of polysacharide
polymer : Pneumococcus,
Klebsiella pneumoniae,
Neisseria gonorrhoe ,
Haemophylus influenzae,
Bacillus anthracis etc.
Anti-phagocytic activity.
Biological activity of
Bacterial enzyme
Catalyses the hydrolysis of the related
component :
Hyaluronidase produced by
Staphylococcus sp and Streptococcus
sp caused hydrolysis of hyalin
component of human tissue such on
skin and mucose
Leukocidin, Haemolysin,
Streptolysin
Making a protein channel
on Cytoplasmic
membranecause cell
death
Figure 15.5
Damaging capacity of
exotoxin
Ex. Shiga and Vero toxin.
Attach as ligand on the
receptor the cell activate
thre formation of porin
release the cytoplasm
component death of the
cell
Figure 15.5
Enterotoxin activity
Ex. Vibrio cholerae enterotoxin
After bacterial colonization- toxin
released-toxin get into the intestinal
mucosalcell activate the adenylate
enzymatic cascade-produced cyclic
-5-AMP- accumulation of cell energyactivate the secretion of water and
electrolyte from the to intestinal
lumen- produced severe secretoric
diarrhea