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Soup on Improvement of
Clinical Symptoms and Platelet
Level in Dengue Patient-A Pilot
Study
Irfan Mohamad (Otorhinolaryngology)
Wan Yus Haniff (Internal Medicine)
Rosline Hassan (Hematology)
Nutritionist / Dietitian
Pharmacology / Biology
Malaysia
In 2007, 48,185 dengue cases were reported,
with 98 deaths
In 2008, during the 1st week, 734 cases including
3 deaths were reported In the 37th week (7-13
September 2008), 837 cases reported (with 3
deaths)
Source : Disease Control Division, Ministry of
Health Malaysia, epid Week 1& 37, 2008
Globally
More than 500,000 people mostly children
and infants contract this more severe form of
dengue, which kills 20,000 every year, making it
a leading cause of childhood death in many
countries. And the numbers are increasing.
Dengue fever climbs the social ladder.
Nature 448, 734 - 735 (2007) .
doi:10.1038/448734a
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Promising?
Several vaccine developers have utilized
live-attenuated live tetravalent vaccines
and two of them have already completed
phase two trials. However, the risk of
antibody-dependent enhancement infection
is not well elucidated.
Morita K. Dengue vaccines. Nippon Rinsho. 2008
Oct;66(10):1999-2003.
No published data to show the effect of taking crab meat on any disease
Nutritive value of crabs described
Old generation people believe that taking crab meat soup is very helpful in
treating some illnesses including dengue
Nutritive value
The crab showed higher protein content
(78.50%) when compared to the mussel
(63.75%) and the oyster (40.14%).
As to wet weight basis, the lipid contents
were quite low ranging from 0.25 to
1.19%.
Objectives
General
1. To demonstrate the effect of taking
mangrove crab soup meal on the
improvement of dengue patient condition
Specific
1. To evaluate the pletelet count
2. To evaluate the clinical symptom*
Clinical symptom
Headache
Myalgia& athralgia
Fever
Rash
Methodology
Patient clinically diagnosed dengue admitted
Patients randomized into two groups(sex, age
matched)
Baseline blood investigation taken
Supportive treatment commenced
One will received mangrove crab soup as the
first meal since admission
Platelet monitored from the usual BD/QID blood
investigation
Temperature, symptoms, length of stay recorded
Patient selection
Inclusion criteria
1. All patient admitted clinically diagnosed
as dengue
2. Age 18 years old & above
Exclusion criteria
1. Allergy to seafood
2. Patient in shock / intubated
Sample Size
A Pilot Study
30 patients required for each group
(Central Limit Theorem-for normal curve
distribution)
Age, sex matched
The soup
Using Mangrove crab
Prepared in the form of soup
Steps of preparation will be standardized
(after discussion with dietitian/nutritionist)
Served as the first meal and completed
until three doses
Each meal contains 500 ml, to be taken
with the ordinary meal served by hospital
The crab
Mud Crab (Scylla serrata) is also known
as Mangrove Crab. It is commonly farmed
in Southeast Asia.
Is it halal? Is it the same with ketam batu?
Oleh itu dari segi hukum Ketam Nipah adalah binatang yang boleh
dimakan..
Outcome
New supportive measure to expedite
recovery of dengue patient
Reduce the load of platelet usage for
transfusion
Shorten the hospital stay
Improve quality of life
Treating natures disease using natures
gift
Thank you