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Coronavirus (MERS-CoV)
Presented by:
Indera bin Mansor (P77052)
Normawati binti Yusoff (P77039)
Hawa Bee binti Ibrahim (P77046)
Noor Hasmadi bin Mohamad Noor
(P77042)
CONTENT
Introduction (Presenter 1)
MERS-CoV Cases (Presenter 1)
First & Only Case in Malaysia (Presenter 1)
Source of Transmission (Presenter 2)
Mode of Transmssion (Presenter 2)
Speculated Transmission (Presenter 2)
Pathogenesis (Presenter 2)
Incubation Period (Presenter 2)
Symptoms (Presenter 3)
People at Risk (Presenter 3)
Treatment (Presenter 3)
Prevention (Presenter 4)
What is
MERS-CoV
INTRODUCTION
Item
Virus type
History of
disease
Originated
MERS-CoV
Lineage C/
SARS-CoV
Lineage B/
Betacoronaviridae
Betacoronaviridae
September 2012
November 2002
Saudi Arabia
China
Until now
Suspected from animal
331 death
36%
725 death
8.76%
Continued
First identified: Saudi Arabia September 2012
two patients who suffered severe
pneumonia (Zaki et al. 2012).
Different from the SARS coronavirus
(Muller et al. 2012).
MERS-CoV CASES
Until 7th Nov. 2014, 23 countries reported
MERS-CoV confirmed case to WHO.
Middle
East
Africa
Saudi Arabia
United
Arab
Emirates (UAE)
Iran
Jordan
Kuwait
Lebanon
Oman
Qatar
Yemen
Algeria
Egypt
Tunisia
Europe
Austria
Holland
Greece
Italy
Germany
France
Turkey
United Kingdom (UK)
Asian
Philippines
Malaysia
America
DISTRIBUTION OF CONFIRMED
CASES (2012 -2014)
MERS-CoV CASES
SOURCE OF TRANSMISSION
Uncertain.
Animal origin?
Speculated animals :
Bats
A number of viruses detected in bats in
Europe and China (Li et al. 2005); Saudi
Arabia (Memish et al. 2013)
MERS-CoV in a bat faeces samples
Camels
Several studies have identified MERS-CoV in
high proportion of camels - Likely reservoir
(Perera et al. 2013 ; Reusken et al. 2013)
MODE OF TRANSMISSION
Unclear.
But most likely thru direct contact
(contamination of the environment)
or inhalation (coughing, sneezing).
Reservoir' or zoonotic transmission
has yet to be identified for MERS-CoV
(Memish et al. 2013).
Continued
Pandemic potential risk for MERS-CoV does
not exceed 5% (Brban et al. 2013). This
indicates a low risk potential for
transmission from person to person
(Cauchernez et al. 2013).
Cases have occurred in a health care
facility
or
among
close
family
members
(Buchholz et al. 2012; Puzelli et al. 2013)
SPECULATED TRANSMISSION
Coronavirus
Agent
Bat
Reservoir
Camel
Host
Person
handling
camel
Transmission
OR
Coronavirus
Agent
Camel
Reservoir
Person
handling
camel
Host
Person
sneezing
Transmission
PATHOGENESIS
People direct contact with
camel or thru inhalation
Coronavirus enter
the respiratory tract
Coronavirus multiplies &
spreads
Symptoms : Hi Fever,
cough etc.
Coronavirus causes injury
to the lung : Pneumonia
INCUBATION PERIOD
Abdominal pain
Cough
Diarrhea
SYMPTOMS
Symptom
Symptom
Vomitting
Sore throat
PEOPLE AT RISK
i.People with low immune system
ii.
Elderly
iii.
Children under 12 years old
iv.
Pregnant women
v.
People with chronic diseases
vi.
Close contact :
Any person who provided care for the patient.
(healthcare worker or family member, or had similarly close physical
contact).
Any person who stayed at the same place.
(e.g. lived with, visited) as the patient while the patient was ill.
(Source : Jadav 2013)
TREATMENT
No specific treatment No vaccine available
Currently awaiting
clinical trial.
Supportive care is
highly effective
DIAGNOSIS
Exposure Information and travel history
Animal exposures
Human exposures
Food exposures
Travel history
Clinical Information
Signs and symptoms at initial presentation.
Dates and results of any ancillary tests
performed
(X-Ray, CT scan)
(Source : WHO 2013)
Continued
Confirmation lab tests
throat swabs samples (throat swab)
test using the 'Real-time Reverse
Transcriptase
Polymerase
Chain
Reaction (RT-PCR)
(Source : Corman et al. 2012)
PRIMORDIAL PREVENTION
To prevent the
emergence of risk
factors
PRIMORDIAL PREVENTION
AVOID of visits to farm animals (especially
camel farm).
Personal hygiene.
AVOID raw food & the use of drinking
untreated water supply.
DO NOT touch the fruit of vegetables that are
not washed.
AVOID direct contact of pilgrims & visitors
from middle east who have symptoms of
respiratory infection (such as fever, cough,
PRIMARY PREVENTION
To Prevent
Infection via :
1. Specific
Protection
2. Health
Promotion
SPECIFIC PROTECTION IN
MALAYSIA
Theres
no
specific
vaccination for MERS-CoV.
Vaccination
:
against
influenza & pneumococcal.
Mask to cover mouth
nose and hand sanitizer.
&
Standee at Airport
Streamer
HEALTH PROMOTION
IN MALAYSIA
Pamphlets
HEALTH PROMOTION
IN MALAYSIA
Health education to the Umrah & Hajj pilgrims
through Hajj Intensive Courses & Course Hajj
pilgrimage undertaken by the Lembaga Tabung Haji
(LTH).
Health advisory issued by
uploaded by the LTH website.
the
MOH
will
be
Info Kesihatan
http://www.moh.gov.m
y
SECONDARY PREVENTION
To Prevent Disease
by :
1. Early Diagnosis
2. Treatment
HEALTH SCREENING
Travellers from
Middle east countries
FEVER
Allow to go
home with
Health Alert
Card
Allow to go home with
BOTH, the :
Health Alert Card
Home Assessment Tool
FURTHER
ASSESSMENT
History taking
Clinical
examination
SEVERI
TY?
REFERENCES
1. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S,
Al-Barrak A, et al. 2013. Epidemiological, demographic, and
clinical characteristics of 47 cases of Middle
East
respiratory syndrome coronavirus disease from Saudi
Arabia:
a descriptive study. Lancet Infect. 13(9):752-61.
REFERENCES
4. ECDC 2014. Severe respiratory disease associated with Middle
East Respiratory Sydrome Coronavirus (MERS-CoV).
http://
www.ecdc.europa.eu/en/publications/Publications/mers-covsevere-respiratory-disease-risk-assessment-16-october-2014.
pdf
(Access on 16 Disember 2014 ).
5. Cauchemez S, Van Kerkhove MD, Riley S, Donnelly CA, Fraser
C, Ferguson NM. 2013.Transmission scenarios for Middle East
Respiratory Syndrome Coronavirus (MERS-CoV) and how to
tell them apart. Euro Surveill [Internet].
18(24).
6. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, EschbachBludau M, et al. 2012. Detection of a novel human coronavirus
by real-time reverse- transcription polymerase chain reaction.
Euro Surveill. 17(39):pii=20285.
REFERENCES
7. Jadav H.A. 2013. Middle East Respiratory Syndrome Corona
Virus (MERS- CoV) : A Deadly Killer. Journal of Pharmacy and
Biological Sciences . Volume
8, Issue
5 , PP74-81.
www.iosrjournals.org. (Access on 16 Disember 2014).
8. Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, et al. 2005. Bats
are natural
reservoirs of SARS-like coronaviruses. Science.
310(5748):676-9.
9. Memish ZA MN, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, et al.
2013.Middle East respiratory syndrome coronavirus in bats,
Saudi Arabia. Emerg Infect .
10. Ministry of Health. 2014. Maklumat terkini berkaitan
jangkitan Middle East
Respiratory Syndrome Coronavirus (MERS-CoV). Wilayah
Persekutuan Putrajaya. 10 Disember 2014.
REFERENCES
12. Muller MA, Raj VS, Muth D, Meyer B, Kallies S, Smits SL, et
al. 2012. Human
coronavirus EMC does not require the SARS-coronavirus
receptor and maintains broad replicative capability in
mammalian cell lines. MBio. 3(6). pii: e00515-12. doi:
10.1128/mBio.00515-12.
REFERENCES
15. WHO. 2013. Guidelines for investigation of cases of human
infection with middle
east respiratory syndrome cornavirus
(MERS-CoV). http://www.who.int/csr/disease/coronavirus
infection/MERS CoV in investigation guideline Jul13.pdf.
(Access on 16 Disember 2014).
16. Zaki AM, Van Boheemen S, Bestebroer TM, Osterhaus
AD,Fouchier RA. 2012.Isolation of a novel coronavirus from a
man withpneumonia in Saudi
Arabia. N Engl J Med.
367(19):1814-20.
Thank You