Cilnidipine + ARBs

Cilnidipine + ARB
Brand Name
ATELEC (Cilnidipine 10 mg)
ATEDIO (Clinidipine 10 mg + Valsartan 80 mg)

Latest Development Phase

Cilnidipine approved in Japan in 1995
FDC approved in Japan in May 2014

DCGI approval
Cilnidipine approved in 2007
FDC Not approved

Indications
for the treatment of mild to moderate hypertension

ATEDIO
Clinidipine 10 mg + Valsartan 80 mg
Approved for HT (Should not be used
for the first-line treatment of
hypertension)

Cilnidipine + ARB
Developer
Jointly
developed
byFuji
Pharmaceutical
Company,
andAjinomoto, Japan

Clinicaltrial.gov: 8 results
CTRI: No results
Pubmed Hits: 207 hits

Viscera
Japan

Patent in India
No record found

Cilnidipine
Distinct 4th generation CCB
Also blocks N-type Ca+2 channels in
addition to L-type Ca+2 channels
Inhibition of sympathetic system
activation

Pleotropic effects
Improves TG levels in diabetics
Inhibits platelet activation

Cilnidipine advantages
over CCBs
Attenuates NE release from
sympathetic nervous system less
reflex tachycardia
Inhibit renal sympathetic nerve
activity efferent arteriolar
vasodilation protects the glomeruli
through the attenuation of glomerular
hypertension

Cilnidipine advantages
over CCBs
Pedal edema less frequent
Shown to cause resolution of pedal
edema in patients switching from
amlodipine to cilnidipine

Cilnidipine advantages
over CCBs
Anti-proteinuric effect greater then
amlodipine
As effective as ACE inhibitor for
control of proteinuria

Urinary protein/creatinine
ratio(mg/g) - Percentage change
from baseline

Cilnidipine advantages
over CCBs
Better 24-hr BP control with
significant restoration of abnormal
nocturnal dipping

Cilnidipine advantages
over CCBs
Switching from L type CCB to
clinidipine decreases proteinuria and
improves renal function (Kyoto
Cilnidipine Study) in patients with
HT and CKD receiving RAS inhibitors

Cilnidipine Combination
No studies found where cilnidipine is
studied alone vs combination with
ACE inhibitors
Among combination with ARBs;
studies are available for valsartan
combination [both efficacy studies
and PK/PD interaction studies]

Available brands
CINOD-T (Ajanta)
Cilnidipine 5/10/20 mg + Telmisartan 40 mg

TRICINOD (Ajanta)
Cilnidipine 5/10 mg + Telmisartan 40 mg +
Chlorthalidone 6.25 mg

Cilnipar T (Wockhardt Ltd)

Cilnidipine 10 mg + Telmisartan 40 mg

Cetanil T (Alembic)
Cilnidipine 10 mg + Telmisartan 40 mg

Available brands
Nexovas O McLoeds
cilnidipine 10 mg, olmesartan medoxomil
20 mg
cilnidipine 10 mg, olmesartan medoxomil
40 mg

TRINEXOVAS McLoeds
cilnidipine 10 mg, olmesartan 20 mg,
chlortalidone 12.5 mg
cilnidipine 10 mg, olmesartan 40 mg,
chlortalidone 12.5 mg

Medical recommendation
Yes
Cilnidipine 10 mg + Valsartan 80 mg

Medical recommendation
Yes
Cilnidipine 5/10/20 mg + Telmisartan
40 mg