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Global Human Growth Hormone Market Report


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Executive Summary

Pituitary - the master gland of human body is responsible for controlling crucial hormonal secretion, which, in turn, regulates other key
aspects of the body such as temperature, growth, thyroid functioning, urination, and production of other hormones. It is a pea sized gland
situated at the base of brain and is a major component of human body as it expedites the response towards the surrounding environment
and settings.

Any deformity or damage to the pituitary gland can adversely impact the production and activity level of the above mentioned hormones,
thereby affecting the body work process and stunting the outcomes especially in the case of growth hormone. Marred pituitary function
leads to either over or under secretion of the somatropin that is the growth hormone. Its over secretion causes disfiguration in the body
parts like hands, face, feet, etc. whereas, its deficiency impedes the growth of body parts/whole body, thus leading to disease states like
dwarfism or gigantism.

It is observed that the growth hormone related problems usually affect children and teenagers, but it is seen to grip adults as well though
to a lesser extent. The major factors which vitiate the pituitary operations thus impairing the GH role include kidney malfunction,
tumors/cancer especially associated with brain. There are some other unknown causes as well which are termed as idiopathic. Earlier, to
deal with these predicaments, growth hormone used to be extracted from the human cadavers but, as time passed and evolution of
technology/tools/techniques/R&D took place, the extraction of GH also got altered and many novel innovations and discoveries were
made in the respective field.

Nowadays, many leading companies are heavily involved in the R&D process for devising longer acting and sustained release versions of
the somatropin which are produced using the recombinant technology. The competition prevalent in the respective industry is heating up
day by day. The human growth hormone market is monopolized by a few players viz. Pfizer, NovoNordisk, Eli Lilly, Sandoz and Roche.

The global HGH report discusses the key ongoing trends like global agreement for Long-Acting Human Growth Hormone (HGH-CTP),
increasing use of biosimilar version of drugs and continuous growth of recombinant growth hormones market. On the industry
development front, the current inclination is towards developing better treatments for Alzheimers disease and advancements in needle
free injections technology. Furthermore, the major factors driving the HGH market include rising cancer and CKD/ESRD cases and
increasing healthcare expenditure on worldwide basis. In addition, a few factors posing challenges in front of the HGH industry are the
problems in diagnosis of growth hormone deficiency, risks associated with use of recombinant growth hormone therapies and off-label
HGH use which, to an extent, are hindering the growth and development of the same.

By combining SPSS Inc.s data integration and analysis capabilities with our relevant findings, we have predicted the future growth of the
industry. We employed various significant variables that have an impact on this industry and created regression models with SPSS Base
to determine the future direction of the industry. Before deploying the regression model, the relationship between several independent or
predictor variables and the dependent variable was analyzed using standard SPSS output, including charts, tables and tests.

The Growth Hormone market is expected to grow on account of long acting therapies and the growth is
also coming from approval of new agents
Global Human Growth Hormones Market by Value (2010-2015*)

In 2014, the global market for human growth hormone

reached US$... billion based on key drug sales, a decline of
% compared to US$... billion in 2013 registering a CAGR
of % from 2010-2014.
The HGH market reached Kg in terms of volume from
Kg in the previous fiscal registering an annual growth
rate of %. During 2010-2014, the market registered a
CAGR of %.
The key products representing global HGH market
included NovoNordisks Norditropin, which constituted
around ..% of the global market share, Pfizers Genotropin
with ..%, followed by Eli Lillys Humatrope with ..% and
Sandozs Omnitrope with ..% share in 2014.
The human growth hormone market grew rigorously in the
developed geographies like the US, Canada, Europe, and

Global Human Growth Hormones Market by Volume (2010-2015*)

Global HGH Market Share (2014)

In 2014, the global market for human growth hormone reached US$... billion based on key drug sales.

Global HGH Sales by Growth Disorder Indication ( 2015E)

The primary indications in children are pediatric GHD which is estimated
to have a maximum contribution of % followed by idiopathic short
stature (ISS) with a contribution of % of the total revenue. The third
highest contributor is Turner syndrome with % share.
The global market is estimated to be split roughly by ..-..% use in
pediatrics and ..-..% use in adults.
The worldwide pediatric growth hormone deficiency market is estimated
to grow to US$... million by 2020 from US$... million in 2014. The
estimated annual growth rate was ..% for 2014.
The US pediatric GHD market is estimated to reach US$... million in
2020 from US$... million in 2014. The annual growth rate for 2014 stood
at % and is estimated to reach % by 2020.

Worldwide Pediatric GHD Market Opportunity (2014-20120E)

The U.S. Pediatric GHD Market (2014-2020E)

Given the multiple diseases that can be treated with rGH and concordant increasing use of treatment, the
market has been growing continuously
European Pediatric GHD Market (2014- 2020E)
The European pediatric GHD market is estimated to reach US$...
million by 2020 from US$... million in 2014. The market is
estimated to experience modest growth along with estimated
penetration of ..% within 7 years from 2014.
Japans market for GHD is estimated to reach US$... million by
2020 from US$... million in 2014. The annual growth rate for 2014
stood at %.
After the anticipated launch, the global opportunity for VRS-317 is
estimated to be US$... million for the year 2018, and is further
expected to be worth US$... million by 2024, at a CAGR of %.
The global HGH market is forecasted to reach US$... billion in
2018 as compared to US$... billion in 2015.The same is expected
to record a CAGR of about % for the period spanning 2012 to
Japans Pediatric GHD Market (2014- 2020E)

Global Human Growth Hormones Market Forecast (2012-2018E)

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