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Pathophysiology
Therapeutics
ANS
Disease State
Management
Pharmacology
MCMP 407
Sympathetic
Parasympathetic
MCMP 407
How do we define neuron types in the ANS?
Parasympathetic
O
C
CH3
Sympathetic
HO
CH3
CH2
CH2
CH3
HO
CH
Acetylcholine CH3
NH2
OH
Norepinephrine
HO
CH3
H 3C
CH2
CH2
Muscarine
N
CH3
HO
CH3
CH3
N
Nicotine
(Noradrenaline)
HO
CH
CH2
OH
Epinephrine
(Adrenaline)
NH
CH3
MCMP 407
Parasympathetic Ganglionic Synapse
Ca 2+
Acetylcholinesterase
Na+
ACH
Action Potential
Na
Preganglionic neuron
Nicotinic
Receptor
Postganglionic neuron
MCMP 407
Parasympathetic Organ Synapse
Acetylcholinesterase
Ca 2+
Effector
Organ
Na+
K+
G
Action Potential
ACH
Muscarinic
Receptor
Postganglionic neuron
MCMP 407
Summary of parasympathetic neurons
and synapses
Preganglionic neurons
Long
Synapse with postganglionic neurons at or near organ
Release acetylcholine (ACH) to activate nicotinic receptors on
postganglionic neurons
Postganglionic neurons
Short
Synapse on the target organ
Release acetylcholine (ACH) to activate muscarinic receptors on
the target organ
MCMP 407
Sympathetic Ganglionic Synapse
Ca 2+
Acetylcholinesterase
Na+
ACH
Action Potential
Na
Preganglionic neuron
Nicotinic
Receptor
Postganglionic neuron
MCMP 407
Sympathetic Organ Synapse
Ca 2+
Effector
Organ
Na+
Action Potential
G
NE
Adrenergic
Receptor
Postganglionic neuron
MCMP 407
Summary of sympathetic neurons
and synapses
Preganglionic neurons
Short
Synapse with postganglionic neurons near spinal cord
Release acetylcholine (ACH) to activate nicotinic receptors on
postganglionic neurons
Postganglionic neurons
Long
Synapse on the target organ
Release norepinephrine to activate adrenergic receptors on target
organs
MCMP 407
Exceptions in the sympathetic nervous system:
Sweat glands:
Postganglionic neurons
involved with stress-related
excretion release
norepinephrine (sweaty
palms)
Postganglionic neurons
involved with
thermoregulation release
acetylcholine
MCMP 407
Exceptions in the sympathetic nervous system:
Kidneys:
Postganglionic neurons to the
Adrenal gland:
Preganglionic neurons do not
MCMP 407
How do drugs influence the ANS?
MCMP 407