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Lecture 19
Altitude training:
Traditionally athletes would live at High
Altitude camps (8000ft above sea level) for
several weeks before the event)
More common practice now is to have
athletes sleep in high altitude tents or live in
high altitude houses.
Hemoglobin carries O2
in the blood to working
muscles.
Athletes that live high and compete low (at
sea level where there is normal O2 in the
air) have increased carrying capacity of O2
and consequently greater O2 delivery to
tissues. This increases aerobic performance
and speeds up the recovery process.
Erythropoietin (EPO)
Glycoprotein hormone that stimulates
erythrocyte (RBC) precursors in the bone
marrow.
Produced by our kidney
Regulates RBC production
Synthetic EPO is available as a therapeutic agent
produced by recombinant DNA technology in
mammalian cell culture
- used traditionally to treat anemia (decrease in
the number of healthy RBC) as a result of
cancer or chronic renal failure
- also used as a common blood doping agent in
endurance sports
EPO
EPO
EPO
EPO
EpoR
EpoR
EpoR
EpoR
Higher O2
in the blood
feedbacks
to kidneys
When O2 is LOW
Bone (marrow
not shown)
O2
Performance
Muscle