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CHAPTER

27
The Reproductive
System

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27-2

Learning Outcomes
27.1 List the organs of the male reproductive
system and give the locations, structures,
and functions of each.
27.2 Describe how sperm cells are formed.
27.3 Describe the substances found in semen.
27.4 Describe the process of erection and
ejaculation.

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27-3

Learning Outcomes (cont.)


27.5 List the actions of testosterone.
27.6 Describe the causes, signs and symptoms,
and treatment of various disorders of the
male reproductive system.
27.7 List the organs of the female reproductive
system and give the locations, structures,
and functions of each.
27.8 Explain how ova develop.
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27-4

Learning Outcomes (cont.)


27.9

List the actions of estrogen and


progesterone.

27.10 Explain how and when ovulation occurs.


27.11 Describe what happens to an ovum after
ovulation occurs.
27.12 List the purpose and events of the
menstrual cycle.
27.13 Define menopause and explain what
causes it.
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27-5

Learning Outcomes (cont.)


27.14

Describe the causes, signs and symptoms,


and treatments of various disorders of the
female reproductive system.

27.15

Explain how and where fertilization occurs.

27.16

Describe the process of implantation.

27.17

Explain the difference between an embryo


and a fetus.

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27-6

Learning Outcomes (cont.)


27.18

Describe the changes that occur in a


woman during pregnancy.

27.19

List several birth control methods and


explain why they are effective.

27.20

List the causes of and treatments for


infertility.

27.21

Describe the causes, signs and symptoms,


and treatments of the most common
sexually transmitted diseases.
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27-7

Introduction
Male and female reproductive systems
Function together to produce offspring
Female reproductive system nurtures
developing offspring
Produce important hormones

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27-8

Male Reproductive System

Testes
Primary organs
Develop in the abdominal
pelvic cavity of fetus

Scrotum sac that holds


the testes
Seminiferous tubules
On top of testes

Descend into scrotal sac


shortly before or after birth

Filled with spermatogenic


cells that produce sperm
cells

Produce the male sex cells


(sperm)
Produce the male hormone
testosterone

Interstitial cells produce


testosterone

Male
System

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27-10

Spermatogenesis
Spermatogenesis

Spermatogonia (46 chromosomes)


Mitosis makes primary spermatocytes
Undergo meiosis two secondary spermatocytes
Divides two spermatids = 4 spermatids
Develop flagella to become mature sperm cells
with 23 chromosomes

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27-11

Sperm Cells
Head
Nucleus with 23
chromosomes
Acrosome enzymefilled sac

Tail
Flagellum that propels
sperm forward

Helps sperm penetrate


ovum

Midpiece
Mitochrondria that
generate cells energy

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27-13

Male
Internal Accessory
Organs
Epididymis
Seminal
vesicle
Sits on top of each testis
Receives spermatids from
seminiferous tubules
Spermatids become
sperm cells

Vas deferens
Tube connected to
epididymis
Carries sperm cells to
urethra

Secrete
Fluid rich in sugar used to
make energy
Prostaglandins
stimulate muscular
contractions in female to
propel sperm forward

Seminal fluid
Released into vas
deferens just before
ejaculation
60% of semen volume
Male
System

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27-14

Male Internal Accessory Organs (cont.)


Prostate gland
Surrounds urethra
Produces and secretes a
milky, alkaline fluid into
urethra just before
ejaculation
Fluid protects sperm in the
acidic environment of the
vagina
40% of semen

Bulbourethral
(Cowpers) glands
Produce a mucus-like fluid
Secreted just before
ejaculation
Lubricates end of penis

Semen
Alkaline mixture
Nutrients
Prostaglandins

1.5 to 5.0 ml per ejaculate


Sperm count of 40 to 250
million/mL
Male
System
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27-15

Male External Accessory Organs


Scrotum

Penis

Holds testes away from


body

Shaft

Temperature 1 below body


temperature

Glans penis

Lined with serous


membrane that secrets
fluid

Prepuce

Testes move freely

Erectile tissues surround


urethra
Cone-shaped structure on
end of penis
Skin covering glans penis
in uncircumcised males

Functions
Deliver sperm
Urination
Male
System
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27-16

Erection, Orgasm, and Ejaculation


Erection
Parasympathetic nervous system stimulates erectile tissue
Becomes engorged with blood

Orgasm
Sperm cells propelled out of testes into urethra
Secretions from accessory organs also released into urethra

Ejaculation
Semen is forced out of urethra
Sympathetic nerves then stimulate erectile tissue to release
blood
Penis returns to flaccid state

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27-17

Male Reproductive Hormones


Hypothalamus
Gonadotropin-releasing hormone (GnRH)
Stimulates anterior pituitary to release
Follicle-stimulating hormone (FSH) initiates
spermatogenesis
Luteinizing hormone (LH) stimulates interstitial cells
in the testes to produce testosterone

Testosterone
Secondary sex characteristics
Maturation of male reproductive organs
Regulated by negative feedback

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27-18

Apply Your Knowledge


Matching:

ANSWER:

___
D Vasectomy

A. Spermatogenesis

___
F Mixture of sperm and fluids

B. Testes

A Sperm cell formation


___

C. Penis

___
G Secrete alkaline fluid/prostaglandins

D. Vas deferens

B Produce testosterone
___

E. Hypothalamus

E GnRH
___

F. Semen

C Erectile tissue
___

G. Seminal vesicle

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27-19

Diseases and Disorders of the Male


Reproductive System
Disease/Disorder

Description

Benign prostatic
hypertrophy (BPH)

Nonmalignant enlargement of the prostate gland;


common in older men

Epididymitis

Inflammation of an epididymis; usually starts as


an urinary tract infection

Impotence or erectile Disorder in which erection cannot be achieved or


dysfunction (ED)
maintained; about 50% of males between 40 and
70 have some degree of ED

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27-20

Diseases and Disorders of the Male


Reproductive System
Disease/Disorder

Description

Prostate cancer

Most common form of cancer in men over 40;


risks of developing it increase with age

Prostatitis

Inflammation of the prostate gland; may be acute


or chronic

Testicular cancer

Malignant growth in one or both testicles; more


common in males 1530 years; more aggressive
malignancy

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27-21

Apply Your Knowledge


Your patient has an elevated PSA. What is a PSA
and what does it indicate?
ANSWER: The PSA is a prostate-specific antigen in
the blood. Elevations of the PSA may indicate
prostate cancer.

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27-22

Female Reproductive System


Ovaries (2)
Primary sex organs produce
Sex cells called ova
Hormones estrogen and progesterone

Located in the pelvic cavity


Medulla
Inner area; contains nerves, lymphatic vessels, and blood
vessels

Cortex
Outer area; contains ovarian follicles

Covered by epithelial and dense connective tissues

Female
System

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27-24

Ovum Formation (cont.)


Primordial follicles
develop before birth and
contain
A primary oocyte or
immature ovum (born with
maximum number)
Follicular cells

Oogenesis is the process


of ovum formation
At puberty, primary oocytes
are stimulated to continue
meiosis
Becomes 1 polar body (a
nonfunctional cell) and
A secondary oocyte

Secondary oocyte released


during ovulation
If fertilized, the oocyte
divides to form a mature,
fertilized ovum

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27-25

Female Internal Accessory Organs


Fallopian tube oviduct
Infundibulum and fimbriae
Fringed, expanded end of fallopian tube near ovary
Function to catch an ovum

Muscular tube
Lined with mucous membrane and cilia
Propels ovum toward uterus
Internal Accessory
Organs

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27-26

Female Internal Accessory Organs (cont.)


Uterus
Hollow, muscular
organ
Receives embryo and
sustains its
development
Divisions
Fundus domed upper
portion
Body main portion
Cervix narrow, lower
section extending into
vagina (cervical
orifice)

Internal Accessory
Organs

Wall of uterus
Endometrium
Innermost lining
Vascular
Tubular glands
mucus

Myometrium
Middle, thick,
muscular layer

Perimetrium
Thin layer covering
the myometrium
Secretes serous fluid
to coat and protect
uterus
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27-27

Female Internal Accessory Organs (cont.)


Vagina
Tubular, muscular organ
Extends from uterus to outside body (vaginal
introitus)
Muscular folds rugae enable expansion
Receive erect penis
Passage for delivery of offspring and uterine secretions

Wall
Innermost mucosal layer
Middle muscular layer
Outer fibrous layer
Internal Accessory
Organs

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27-28

Internal Female Organs

Back

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27-29

External Accessory Organs


Mammary glands
Secretion of milk
Structures
Nipple
Oxytocin induces
lactiferous ducts to
deliver milk through
openings

Areola pigmented area


around nipple
Alveolar glands within
mammary glands
Make milk when
stimulated by prolactin
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27-30

External Genitalia
Collectively known as the vulva
Labia majora
Rounded folds of adipose tissue and skin
Protect other external reproductive organs

Labia minora

Folds of skin between labia majora


Very vascular
Merge to form hood over clitoris
Vestibule space enclosed by labia minora
Bartholins glands secrete mucus during sexual
arousal
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27-31

External Genitalia (cont.)


Clitoris
Anterior to urethral meatus
Contains female erectile tissue
Rich in sensory nerves

Perineum
Between vagina and anus
Area for episiotomy, if needed, during birth
process
External
Genitalia
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Erection, Lubrication, and Orgasm


Nervous stimulation
Clitoris becomes erect
Bartholins glands activate lubrication
Vagina elongates

Orgasm
Sufficient stimulation of clitoris
Walls of uterus and fallopian tubes contract to
propel sperm up tubes

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27-33

Female Reproductive Hormones


Hypothalamus
secretes GnRH

GnRH

Anterior pituitary
releases FSH & LH

tes
a
l
mu
i
t
S

Ovaries to produce
estrogen and
progesterone

Estrogen and progesterone


Responsible for development
of secondary sex characteristics

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27-34

Reproductive Cycle
Menstrual cycle
Regular changes in uterine
lining, resulting in monthly
bleeding

Menarche first menstrual


period
Menopause termination of
cycle due to normal aging of
ovaries

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27-35

Reproductive Cycle (cont.)


Anterior pituitary
releases FSH
Then releases
LH

Ovarian follicle
matures and secretes
estrogen
Triggers
ovulation

Follicular cells
become
corpus luteum,
which secretes
progesterone

Uterine lining thickens


Lining more vascular
and glandular

Without fertilization

Corpus luteum degenerates

Estrogen and progesterone


levels fall

Uterine lining breaks down


menses starts

Cycle begins again with


release of FSH

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27-36

Apply Your Knowledge


True or False:

YIPPEE!

ANSWER:

F The ovaries only produce estrogen.


___

produce estrogen and progesterone

F Ovulation is the process of ovum formation.


___

Oogenesis

T The fallopian tube is also called the oviduct.


___
F The endometrium is the outer layer of the uterine wall.
___

inner layer

T Alveolar glands produce milk.


___
F
___Oxytocin
induces the alveolar glands to deliver milk through the
lactiferous ducts
nipples.
F Menarche is the termination of the menstrual cycle.
___

first

T Menopause occurs due to normal aging of the ovaries.


___
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27-37

Diseases and Disorders of the Female


Reproductive System
Disease/Disorder

Description

Breast cancer

Second leading cause of cancer deaths in


women; classified as stage 0 to 4

Cervical cancer

Slow to develop; Pap smear detects abnormal


cervical cells

Cervicitis

Inflammation of the cervix usually due to an


infection

Dysmenorrhea

Condition with severe menstrual cramps that


limit normal activities

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27-38

Diseases and Disorders of the Female


Reproductive System (cont.)
Disease/Disorder

Description

Endometriosis

Tissues of uterine lining growing outside of the


uterus

Fibrocystic breast
disease

Abnormal cystic tissue in the breast; size varies


related to menstrual cycle; common in 60% of
women between 30 and 50

Fibroids

Benign tumors in the uterine wall; affect 25% of


women in their 30s and 40s

Ovarian cancer

Considered more deadly than other types;


detection difficult and often spreads before
detection

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27-39

Diseases and Disorders of the Female


Reproductive System (cont.)
Disease/Disorder

Description

Premenstrual
syndrome (PMS)

Collection of symptoms occurring just before a


menstrual period

Vaginitis/
vulvovaginitis

Inflammation of the vagina/inflammation of


vagina and vulva; both associated with abnormal
vaginal discharge

Uterine (endometrial)
cancer

Most common in post-menopausal women;


causes about 6% of cancer deaths in women

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27-40

Apply Your Knowledge


Matching:

ANSWER:

___
E Inflammation of the cervix

A. Dysmenorrhea

___
G Cancer common in post-menopausal women

B. Cervical cancer

___
B Develops slowly; detected by Pap smear

C. Fibroids

___
F Uterine tissue grows outside uterus

D. Breast cancer

___
D Second leading cause of cancer death in women E. Cervicitis
___
A Severe menstrual cramps

F. Endometriosis

___
C Benign tumors in the uterine wall

G. Uterine cancer

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27-41

Pregnancy
Pregnancy condition of having a developing
offspring in the uterus
Fertilization process in which a sperm cell
unites with an ovum; results in pregnancy
Only one sperm cell penetrates the follicular cells and
the zona pellucida that surround the ovums cell
membrane
After fertilization, ovum releases enzymes that cause
the zona pellucida to become impenetrable to other
sperm
Zygote forms from union of ovum and sperm
Contains 46 chromosomes
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27-42

The Prenatal Period


Time before birth
Zygote undergoes rapid mitosis
First week after fertilization
Cleavage rapid cell division
Morula ball of cells resulting from cleavage
Travels down fallopian tube to uterus
Becomes blastocyst, which implants in endometrial
wall

Blastocyst
Some cells (inner cell mass) become embryo
Others, along with cells from uterus, form placenta
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27-43

The Prenatal Period (cont.)


Embryonic period
Week 2 through 8
Inner cell mass
organizes into
three primary
germ layers
Ectoderm
Mesoderm
Endoderm

Formation of
Placenta
Amnion
Umbilical cord
Yolk sack
Most internal
organs and external
structures of
embryo

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27-44

The Prenatal Period (cont.)


Last 3 months fetal
brain cells rapidly
divide
GI and respiratory
systems last to
develop

Fetal period
Week 8 through birth
Rapid growth
5th month skeletal
muscles active
6th month gains
weight

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27-45

Fetal Circulation
Placenta and umbilical blood vessels carry
out the exchange of nutrients, oxygen, and
waste products
Unique differences from normal circulation
Foramen ovale hole between right and left
atria enables most of fetal blood to bypass
lungs
Ductus arteriosus connection between
pulmonary trunk and aorta
Ductus venosus vessel that bypasses liver
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27-46

Hormonal Changes During Pregnancy


Embryonic cells secrete human chorionic
gonadotropin (HCG)
Maintains the corpus luteum

Estrogen and progesterone


Secreted by corpus luteum and placenta
Functions
Stimulate uterine lining to thicken, development of mammary
glands, enlargement of female reproductive organs
Inhibit release of FSH and LH from anterior pituitary gland
(preventing ovulation) and uterine contractions

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27-47

Hormonal Changes (cont.)


Relaxin
From corpus luteum
Inhibits uterine
contractions and
relaxes ligaments of
pelvis

Lactogen
From placenta
Stimulates
enlargements of
mammary glands

Aldosterone
From adrenal gland
Increases sodium and
water retention

Parathyroid
hormone (PTH)
Helps maintain high
calcium levels in the
blood

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27-48

Apply Your Knowledge


What are the primary germ layers and what tissue
develops from them?
ANSWER: The primary germ layers are the:
Ectoderm nervous tissue and some epithelial tissue
Mesoderm connective tissue and some epithelial tissue
Endoderm epithelial tissue only

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27-49

The Birth Process


Begins when progesterone levels fall
Prostaglandins secreted by uterus stimulate
uterine contractions
Uterine contractions stimulate posterior pituitary
gland to release oxytocin
Oxytocin stimulates strong uterine contractions

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27-50

The Birth Process (cont.)


Three stages
Dilation
Cervix thins and softens (effacement)
Lasts 8 24 hours

Expulsion or parturition
Actual birth
May take 30 minutes or less

Placental stage 10 to 15 minutes after the


birth, the placenta separates from uterine wall
and is expelled
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27-51

The Birth Process (cont.)


The postnatal
period
Six-week period
following birth
Neonatal period
first four weeks
Neonate is
adjusting to life
outside uterus

Milk production and


secretion
Prolactin production
of milk
Oxytocin ejection of
milk from mammary
gland ducts
Production continues
as long as breastfeeding continues

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27-52

Apply Your Knowledge


What are the three stages of the birth process and
what occurs during each?
ANSWER: The three stages are:

Dilation the cervix thins, softens (effacement), and dilates to


approximately 10 cm

Expulsion also called parturition; the actual birth stage

Placental stage placenta separates from uterine wall and is


expelled

Impressive
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27-53

Contraception
Method

Description

Coitus interruptus

Penis is withdrawn from vagina before ejaculation;


not a reliable method

Rhythm method

Requires abstinence around time of ovulation; not a


reliable method

Mechanical
barriers

Prevent sperm from entering female reproductive


tract

Chemical barriers

Destroy sperm in the female reproductive tract;


primarily spermicides; often used with mechanical
barriers

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27-54

Contraception (cont.)
Method

Description

Oral
contraceptives

Birth control pills; prevent ovulation by preventing


LH surge

Injectable
contraceptives

Prevent ovulation and alter lining of uterus to


prevent implantation of blastocyst

Insertable
contraceptives

Ring inserted vaginally and removed at the


beginning of the 4th week to allow menstruation

Contraceptive
implants

Small rods of progesterone implanted beneath skin;


prevent ovulation

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27-55

Contraception (cont.)
Method

Description

Transdermal
contraceptives

Contraceptives in the form of a patch; applied


weekly for 3 weeks; not used the 4th week to allow
menstruation

Intrauterine device Small, solid devices placed into uterus by MD;


(IUD)
prevents implantation of blastocyst
Surgical methods

Tubal ligation fallopian tube fulgurated to prevent


sperm from reaching oocyte
Vasectomy vas deferens is fulgurated to prevent
ejaculation of sperm

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27-56

Apply Your Knowledge


Your patient has just been told that she is pregnant, but she
does not understand why she could get pregnant. She
states, I have been using the rhythm method of birth
control very carefully. What patient teaching would you do
to assist her to understand?
ANSWER: The rhythm method is not as effective as other
birth control, because it is sometimes difficult to tell when
ovulation occurs.

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27-57

Infertility
Inability to conceive a child
Primary no prior pregnancy, unable to
achieve pregnancy in 12 months
Secondary at least one prior pregnancy,
unable to achieve pregnancy after one year
Causes
15% unknown
35% male-related problems
50% female-related problems

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27-58

Infertility (cont.)
Male-related
Impotence
Retrograde ejaculation
Low or absent sperm
count
Medications/drugs
Decreased testosterone
Scarring from STDs
Prior mumps infection
Inflammation of
epididymis or testes

Female-related
Scarring from STDs
Pelvic inflammatory
disease
Inadequate diet
No ovulation or
menstrual cycle
Endometriosis
Abnormal shape of
uterus or cervix
Hormonal imbalances
Cysts in ovaries
Older than 40 years

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27-59

Infertility (cont.)
Tests
Semen analysis
Monitoring of morning
body temperature
Blood hormone
measurements
Endometrial biopsy
Urine analysis for LH
Hysterosalpingogram
Laparoscopy

Treatments
Surgical repair of
abnormalities
Fertility drugs
Hormone therapies
Artificial insemination
In vitro fertilization
Use of surrogate

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27-60

Apply Your Knowledge


Indicate whether each cause of infertility is male-related (M), female-related
(F), or both (B).
ANSWER:
M Retrograde ejaculation
___
M Mumps infection
___
F Inadequate diet
___
B Scarring from STDs
___

F
___

Pelvic inflammatory
disease

F
___

Hormone imbalances

M
___

Use of some medications

F
___

Being over 40 years old

Very
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27-61

Sexually Transmitted Diseases


STD

Cause

AIDS

HIV virus causes AIDS; described in Chapter 21

Chlamydia

Caused by bacterium; most commonly reported;


often no symptoms in female

Genital warts

Caused by HPV; not everyone infected has


symptoms

Gonorrhea

Bacterial cause

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27-62

Sexually Transmitted Diseases (cont.)


STD

Cause

Herpes simplex

Caused by viruses; type I causes cold sores; type II


commonly known as genital herpes; may be passed
from mother to child during childbirth

Pubic lice

Parasitic infestation; commonly called crabs

Syphilis

Caused by bacteria; decreasing in women but


increasing in males who have sex with other males

Trichomoniasis

Caused by protozoan parasite; also called


trichomonas infection or trich

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27-63

Apply Your Knowledge


Match:

ANSWER:

___
D Most commonly reported STD in the U.S.

A.

___
F Two types; both caused by a virus

B.

___
E Crabs

C.

___
C Increasing incidence in males

D.

___
A Common bacterial STD; can also grow in mouth E.
___
B Caused by HPV virus

S
Gonorrhea
U
Genital warts
P
Syphilis
E
Chlamydia
R
Pubic lice
!

F. Herpes simplex

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27-64

In Summary
27.1 The organs of the male reproductive system include
the testes, responsible for sperm and hormone
production, and the accessory organs of vas
deferens, seminal vesicles, prostate and bulbourethral
glands, scrotum, and penis.
27.2 Spermatogenesis begins in the seminiferous tubules
of the testes. They mature in the epididymis first as
spermatogonia, then as spermatocytes, and finally as
spermatids.

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27-65

In Summary (cont.)
27.3 Semen is a mixture of seminal fluid, prostatic fluid,
sperm cells, and lubricating bulbourethral fluid.
27.4 Erection occurs during sexual arousal, causing penile
engorgement with blood. Ejaculation occurs when
semen and its sperm cells are forced out of the body
through the urethra.
27.5 Testosterone is responsible for the male secondary
sex characteristics and maturation of the male
reproductive organs.

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27-66

In Summary (cont.)
27.6 The diseases of the male reproductive system vary
widely between simple inflammation and cancers. The
more common diseases and disorders, with their
varied symptoms and treatments, are outlined in the
Pathophysiology section of this chapter, immediately
following the A&P of the male reproductive system.
27.7 The organs of the female reproductive system include
the ovaries, fallopian tubes, uterus, and vagina. The
external accessory organs include the mons pubis,
labia majora and minora, clitoris, urethral meatus,
vaginal orifice, Bartholins glands, perineum, and
mammary glands.
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27-67

In Summary (cont.)
27.8 Ova originate from the primordial follicles within the
ovaries present during fetal development, which
produce the oocyte and follicular cells responsible for
oogenesis.
27.9 Estrogen is responsible for female secondary sex
characteristics. Both estrogen and progesterone
stimulate the uterine lining to thicken in preparation
for pregnancy and inhibit uterine contractions during
pregnancy.
27.10 Ovulation occurs when the anterior pituitary releases
a surge of LH, causing the release of a mature ovum.
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In Summary (cont.)
27.11 The follicular cells become the corpus luteum, which
releases more progesterone, which causes the
uterine lining to become more vascular and glandular
to prepare for the pregnancy.
27.12 The female menstrual cycle causes periodic changes
in the uterine lining. After a menstrual period, the
body prepares for the next ovulatory cycle with
increasing levels of estrogen and progesterone. If
pregnancy does not occur, these levels drop, causing
the uterine lining to break down and resulting in the
next menstrual period.

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In Summary (cont.)
27.13 Menopause is the cessation of the menstrual cycle
related to normal aging of the ovaries.
27.14 The diseases of the female reproductive system vary
widely between simple inflammation and cancers.
The more common diseases and disorders, with their
varied symptoms and treatments, are outlined in the
Pathophysiology section of this chapter, immediately
following the A&P of the female reproductive system.

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In Summary (cont.)
27.15 Fertilization occurs with the union of a sperm cell and
ovum; usually occurs within the fallopian tubes, but
may occur anywhere in the female reproductive tract.
27.16 The fertilized ovum, now a blastocyst, implants in the
endometrial wall of the uterus.
27.17 The embryonic period occurs from week 28 of the
pregnancy, and the fetal period is from week 9
through delivery.

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27-71

In Summary (cont.)
27.18 Hormonal changes stimulate the uterine lining and
inhibit FSH and LH production to prevent ovulation.
Mammary glands are stimulated and enlarged,
uterine contractions are inhibited, and the pelvic
ligaments loosen in preparation for delivery.
27.19 Some of the contraceptive methods include coitus
interruptus; barrier methods; chemical barriers; oral
contraceptives; injectable, implantable and insertable
contraceptives; and intrauterine devices. Their
mechanisms are discussed in detail within the
chapter.

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In Summary (cont.)
27.20 The causes of infertility are varied, with about 15% of
infertility for unknown causes. A number of infertility
tests and treatments are discussed within the
chapter.
27.21 There are many sexually transmitted diseases, all
passed between sexual partners (heterosexual and
same-sex partners alike). Their symptoms,
treatments, and sequelae for both sexes are
discussed in detail in the Pathophysiology section
devoted to STDs at the end of this chapter.

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End of Chapter 27
The
reproduction of
mankind is a
great marvel
and mystery.
~Martin Luther

2011TheMcGrawHillCompanies,Inc.Allrightsreserved.

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