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Allergy testing
Presented by
Universit
de Montral
Assessment of Allergy
The
term "Allergy"
Allergic
reaction
Assessment
Skin
of atopy
or immunological testing
What is Allergy?
Also known as
Hypersensitivity
Disease
Definition
The term allergy ( von Pirquet -1906),
can be summarized as the acquired,
specific, altered capacity to react.
From Greek words: allos "change, altered"
+ ergon "reaction, reactivity".
Acquired means prior adequate
antigenic or allergenic exposure.
Lower
rate of breast-feeding ?
Exposures
Exposure
The
to air pollution?
"hygiene hypothesis"?
Classificationofallergicreaction
byGell&Coombs*
TypeI
Anaphylaxis(IgE)
(immediate)
TypeII
Cytotoxic
Atopicdiseases
TypeIII
Immune complex
(IgG)
Farmerslung
TypeIV
Delayedallergy
Autoimmune hemolytic
anemia
Firstpublishedin1968:Clinicalaspectsof
immunology
Assessment of Atopy
Epidemiologic studies
Occupational investigation
Skin
dust mite
Ragweed, tree pollen
Pets
Cockroaches
Molds
Occupational protein
allergens
Advantages
Introduction of allergen
extract into the dermis
Ig-E-mediated response
Technique
INTERPRETATION
Read
CONCLUSIONS
When properly performed, skin tests
represent one of the major tools for
diagnosis of Ig-E-mediated diseases.
Assessment of the atopic status of subjects
is often included in epidemiological studies
of asthma and occupational asthma because atopy
is a risk factor.
before
same time
PPV
21
18
14
17
9
22
17
16
19
4
28%
30%
21%
30%
9%
references
- Bernstein IL, Chan-Yeung M, Malo JL, Bernstein DI. Asthma in the
Workplace. Francis & Taylor, 2006
- Middletons Allergy: Prinnciples and practice vol. 1,chap 38.
- Pepys, J. Clinical allergy, 1973, pp 491-509.
- Pepys, J. Atopy: a study in definition. Allergy 1994;49: 397-399
- Bernstein DI and al.Characterization of skin prick testing responses
J Allergy Clin Immunol 1994; 49:498-507
Web sites of interest
- www.asthma-workplace.com
- www.asthme.csst.qc.ca/document/Info_Gen/AgenProf/
- www.remcomp.com/asmanet/asmapro/index.htm