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British Biologicals
The Protein People
Dr.Roopa.S
Nutritionist
Nutrition
Nutrition
Nutrition:
It is the science that deals with
digestion, absorption metabolism
of food, i.e., the utilization of food
in the body.
(Nutrition; An integrated approach1984 3rd
ed)
Nutrition
Food is utilized in the body in three ways
It is oxidized by the bodys cells to produce energy.
It is incorporated into new cells & tissues to promote growth.
It is used to repair & replace damaged body tissues.
Optimum nutrition:
It is eating the right amount of nutrients on a proper schedule to
achieve the
Best performance
The longest possible lifetime in good health
Avoidance of accidents & infectious diseases
Nutrition
Balanced diet
diet
Unbalanced
Nutrition
Malnutrition
Under nutrition
Inadequate intake of food
Or body is not able to
Utilize food properly
Because of disease condition
Over nutrition
Over intake of food relative to
what is required for normal
growth & development
Homeostasis
Homeostasis
It is the maintenance of a constant balanced environment in the
body. It is very important because when it falls it causes diseases
&
sometime death.
Body cells work best if they have the correct
Temperature
Water levels
Glucose concentration
Receptor - Receives the information that something in the
environment is changing
Control center Receives & processes the information from the
Receptor
Effectors Responds to the commands of the control center by
opposing or enhancing the stimulus.
Body temperature
regulation
Mechanism
to cool the body down
Vasodilation
Blood glucose
homeostasis
If there is too much glucose in the blood, insulin converts some of it to
glycogen.
If there is not enough glucose in the blood, Glucagon converts some
glycogen into glucose.
Glycogen
n
i
l
u
s
Glucagon
In
Glucose in blood
Water homeostasis
Kidney clean the waste products from blood & control how much
water is kept in the body. The waste products & water make up
urine
which is excreted via the ureter.
If there is too little water in the blood, then very
concentrated urine
will be produced (very little water in it).
If there is too much water in the blood, then dilute urine
will be
produced (lots of water in it).
Homeostasis
Homeostasis is governed by.
Adequate supply of nutrients.
Balance between nutrients.
Normal complement of enzyme systems.
Secretion of hormones that regulate metabolic rates.
Nutrition
RDA (Recommended dietary allowances) /RDI (reference daily
Recommendations
intake)/
RNI (reference nutrient intake)
RDA was established by Food & Nutrition board of (US) National
Academy of Sciences
In India RDA is regulated by ICMR (Indian Council of Medical
Research)
Nutrition
Recommendations
RDA
for elderly (51 years & older)
RDA for elderly is recommended by National Academy of Sciences,
Washington DC in 1989.
Middle adulthood : 40-59 years
Late adulthood : 60-70 years
Old age : > 80 years
RDA are not assigned to meet the nutrient requirements of
elderly
individuals with medical problems or at nutritional risk.
Elderly with nutritional risk require different requirements for
energy,
protein, vitamins & minerals.
Energy
Energy requirement (ER): (World Health Organization, 1985)
ER of an individual is the
Energy intake from food which should balance the energy expenditure
Energy requirement
Basal Metabolic Rate (BMR)- 60-70% of energy needed by the
body.
Energy used by the body at complete rest
It is energy used for activities like breathing, circulation,
regulation
of body temperature & synthesis of new tissues.
Breathing
Circulation
Energy Requirement
Regulatory thermogenesis:
Energy used in digesting, absorbing, storing &
disposing of ingested food. (5-10 % energy
needed by the body)
Energy used in response to stimulus & drugs.
(7% of energy)
Energy
Unit of ER: Kcal (Kilo calorie)
1 Kcal= 1000 calorie.
Atwater factors- system for giving energy values to the food.
99% carbohydrate, 92% protein & 95% fat are normally
absorbed.
Atwater factors for energy of food
Carbohydrate - 4 Kcal per gm
Protein
- 4 Kcal per gm
Fat
- 9 Kcal per gm
Alcohol
- 7 Kcal per gm
Only carbohydrate, protein, organic acid, ethanol & fat contain
energy
Water, vitamins, minerals, antioxidants, caffeine & natural flavors
contain zero calories.
Energy Balance
Positive energy
Balance
(Fat deposition)
Negative
Energy
Balance
(Fat
Loss)
Nutrients
Nutrients are active chemical components of food which supplies
energy, regulate body processes & promote growth &
repair of
body tissue.
Micronutrient
Water
Carbohydrate
Protein
Fat
Vitamins
Minerals
Carbohydrates
Sugars, Starches,
Fibers
Major food sources:
plants
Formed during
photosynthesis
Photo PhotoDisc
Simple carbohydrates
Monosaccharides: single sugar unit
Glucose
Found in fruits, vegetables & honey
Blood sugar used for energy
Fructose
Found in fruits, honey corn syrup
It is a source of energy
Galactose
Found as part of lactose in milk
Simple carbohydrate
Disaccharides: two linked sugar units
Sucrose: glucose + fructose
Table sugar made from sugar cane &
Sugar beet.
Lactose: glucose + galactose
Milk sugar found in milk & dairy products
Complex carbohydrates
They are the chain of more than two sugar molecules
Oligosaccharides: chain of 3-10 sugar molecules
Fructooligosaccharide (FOS) is an oligosaccharide
It is found in banana & onion.
It promotes intestinal health by encouraging the growth of friendly
bacteria.
Polysaccharides: chain of 100s or 1000s of monosaccharide
units.
Starch:
Long chain of glucose units
Starch is found in grains, vegetables & legumes.
Glycogen:
Highly branched chains of glucose units
Glycogen in the bodys storage form of carbohydrate.
Complex carbohydrate
Dietary fiber: indigestible chain of monosaccharides
Obtained from plants & human beings lack the enzyme to digest it.
Dietary fiber is classified as soluble & insoluble fiber.
Type of fiber
Soluble fiber
Fermented by
Intestinal bacteria
(soluble in water)
Insoluble fiber
Not fermented
Intestinal bacteria
(insoluble in water)
Major food
sources
Fruits (apple, citrus)
oats, barley, legumes
Actions in body
Dietary fiber
Soluble fiber
Soluble fiber
Food
Body
Intestinal bacteria
fermentation
Viscous gel
Carbohydrate digestion
Mouth :
CHO salivary amylase
maltose + polysaccharide
Sucrase
maltase
lactase
disaccharide
Glucose + fructose
Glucose + Glucose
Glucose + Galactose
Glucose, galactose & fructose enters into the absorptive intestinal cells.
After absorption they are sent into the liver where galactose & fructose
are
converted into glucose & release into the blood stream.
Glucose is sent directly to organs that need energy or transformed into
glycogen for storage in the liver or muscles or it is converted to fat &
store
in adipose tissues.
Glycolysis
The molecular bond of food do not yield high amounts of energy
when broken down.
The energy contained in the food is released within cells & stored
in the form of ATP (Adenosine triphosphate).
CHO are metabolized & used to produce ATP through the process
of glycolysis.
Glycolysis break down glucose in the cells & produces molecules
of ATP.
Through glycolysis glucose is efficiently used in the production of
energy for the body.
Recommended CHO intake
CHO should contribute 55-60 % of total energy intake
10 % should be sugar & 30g/d fiber is recommended.
Lactose intolerance
It is the inability to metabolize lactose because of lack of enzyme
lactase in
the digestive system.
Undigested
Stomach cramp
lactose from
small intestine
colon
Colon
passes Bacteria
into
of lactose
Fermentation
& gas
metabolism
production
Celiac disease
Celiac disease is a digestive disease & people with celiac disease
cannot tolerate protein (gluten) in wheat.
When celiac disease individuals eat foods containing gluten, their
immune system responds by damaging intestinal Villi which interferes
with absorption of nutrients from food.
In adults
Protein
Egg, milk, soybean
Major food sources
animal
Protein
Protein consists of one or more polypeptides
Can be compared with a chain of beads
polypeptide =
protein
Building unit is amino acids
Protein
Amino acids are folded in a 3-dimentional structure
Protein contains
C= carbon
H= Hydrogen
O=Oxygen
N=Nitrogen
N is the key element for building tissues
Simple protein: consists of only amino acids (globulin)
Complex protein: consists of amino acids & non protein
substances
(hemoglobin= Heme + globin)
Protein
Amino acids are of two types
Essential amino acids ( indispensable amino acids)
Cannot be synthesized by our body therefore it should be
supplied through food.
Branched chain amino acids ( BCAA)
These are the EAA which are not metabolized in liver but in
muscles
They are used by the muscles directly in liver diseases.
Non essential amino acids
They can be synthesized in the body.
Conditionally essential amino acids
They are non essential amino acids which become essential
during some particular conditions such as diseases.
Leucine
Isoleucine
Valine
Protein sources
BCAA %
26%
Milk protein
21%
Egg protein
20%
Muscle protein
18%
18%
Wheat protein
15%
Pepsin + HCL
Small intestine
Proteoses & peptones trypsin & chymotrypsin small polypeptides +
free AA
Polypeptides carboxypeptidases lower peptides + free AA
small intestine wall
Peptides peptidases free amino acids
Free amino acids are absorbed by intestinal cells & enter into the
liver & metabolized by the liver or to be used for protein
synthesis in
the tissues.
Requirement for protein in human
10% energy requirement should come from protein.
Dietary protein
digestion
Amino acids
Hormones, enzymes,
Neurotransmitters,
Heme, amino alcohols
Glucose
Piruvate
Fatty acids
Carbon
skeleton
Acetyl Co A
Ketone
Citric
acid
cycle
ammonia
ATP
Urea
Functions of protein
Protein function
Importance
Example
Structural
element
Immune system
White blood
cells
Protection
Enzymes
Sucrase,
maltase
Hormones
Hemoglobin
Rhodopsin
Retinal protein
Nitrogen balance
Obligatory nitrogen losses: Nitrogen loss from the body even when there is
no
protein is being consumed.
Nitrogen balance can be calculated as
Amount of nitrogen consumed- amount of nitrogen lost from the body
Zero nitrogen balance
Amount of protein or nitrogen consumed = amount of obligatory nitrogen loss
Negative nitrogen balance
Amount of protein or nitrogen consumed < amount of obligatory nitrogen loss
Positive nitrogen balance
Amount of protein or nitrogen consumed > amount of obligatory nitrogen loss
Zero nitrogen balance is maintained with greater inflow & outflow of nitrogen
Greater proportion of dietary protein being used as a source of energy
Positive nitrogen balance occurs in children, pregnant woman or
individuals recovering from illness or surgery, whose body require
extra
protein to build tissue.
Protein quality
Protein quality: It is the measure of the usefulness of dietary
protein for
growth & maintenance of tissues.
Biological value (BV): it measures the amount of nitrogen retained
from consumption of protein compared to the amount of nitrogen
consumed.
BV indicates both how digestible is the protein is & how available
the protein is for the use by the body
whole egg -100%,
Protein quality
Protein digestibility corrected amino acid score (PDCAAS):
It measures EAA in a protein compared to reference protein
The reference protein meets the EAA requirement of (2-5 year
children) humans with a PDCAAS of 1.0
It is a standard measure of protein quality ( Food & Agriculture
Organization )
Protein digestibility (PD) : it is the % of protein eaten that is
absorbed
in the body
PD
PDCAAS
Soy protein
95%
1.00
Whey protein
99%
1.00
Fat
Butter, cooking oil
Major food sources
Plant & animal
Fat (Lipids)
Fat :
It consist of fatty acid (chains of carbon & hydrogen atoms,
with a
carboxylic group at one end) bonded to a glycerol.
It is a major source of fuel energy for body
It aids in the absorption of fat-soluble vitamins
Classified as
Fat
Description
Food source
1. Saturated fat
No double bond
2. Unsaturated fat
Double bond
Fat digestion
Stomach
Fat lingual lipase & gastric lipase fatty acid
(triacylglycerol)
Small intestine
Gall bladder secrete bile. Bile salts emulsify fat droplets so as to increase
their surface area.
Triacylglycerol pancreatic lipase 2 Fatty acid + monoglycerol
Cholesteryl ester Cholesteryl hydrolase cholesterol + fatty acid
Micelles of free fatty acid, monoglycerol, cholesterol & bile acids
approach the brush border membrane of the intestinal mucosa for
absorption.
In mucosal cells fatty acids & monoglycerides are recombined to form
triacylglycerol
Triacylglycerol + cholesterol + phospholipids + proteins form a lipoprotein
complex called chylomicrons.
Requirement of fat in human: fat intake < 35% of total energy intake
saturated fat < 15% of total energy intake
Lipid transport
Lipids are insoluble in water & still have to be transported around the
lipoproteins
body.
The insoluble lipids are transported in association with various
proteins as lipoproteins.
Types of lipoprotein
Class of lipoprotein
Main
source
Function
Chylomicrons (CM)
intestine
liver
Intermediate density
lipoprotein (IDL)
VLDL
VLDL
Liver
Functions of Fat/lipid
Type of dietary
fat
Saturated fat
Functions
-Energy source, structural component of cell membrane
& associated with protein functions.
Mono
unsaturated fat
(MUFA)
Omega-3 PUFA
Vitamins
Vitamin:
organic compound that cannot be
synthesized by the body in sufficient
quantities.
They are needed in small amounts for normal
metabolism, growth & maintenance of body
tissues.
Fat soluble vitamins (Vit A, D,E, K):
They dissolve in fat & absorbed from the small
intestine along with dietary fat.
They can be stored in liver or adipose tissue
Water soluble vitamins (Vit C & B complex):
They are absorbed in intestine , pass directly
to the blood & are carried to the tissues in
which they are utilized.
They cannot be stored in the body.
Functions
Sources
Vitamin A
Vitamin D
Maintenance of calcium
concentration in the body
Vitamin E
Antioxidant, prevent
propagation of free radicals
Vitamin K
Functions
Sources
Vitamin C
(Ascorbic acid)
Vitamin B1
(Thiamine)
Vitamin B2
( Riboflavin)
Vitamin B3
(Niacin)
Vitamin B6
(Pyridoxine)
Vitamin B9
(Folic acid)
Vit B12
(Cobalamin)
Vit B5
(Pantothenic acid)
Vit B7 (Biotin)
Minerals
They are the chemical elements other
Than carbon, hydrogen, nitrogen & oxygen
They are required in appropriate amount to
Maintain optimal health.
They play important role in nervous system
Functioning, in cellular reactions, water
Balance in body & structural & skeletal system.
Macro minerals
Minerals
Functions
Sources
Calcium (ca)
Phosphorus
(P)
Sodium (Na)
Processed meat,
canned vegetable
Potassium (K)
Vegetables, fruits,
milk, dates, prune
Magnesium
(Mg)
Chloride
Micro minerals
Minerals
Functions
Sources
Zinc (Zn)
Iron (Fe)
Meat, soybean,
spinach,
Iodine (I)
Copper
(Cu)
Micro minerals
Minerals
Functions
Sources
Manganese
(Mn)
Whole grain
cereals, leafy
vegetables, nuts
Selenium
(Se)
Seafood, whole
grains,
vegetables, garlic,
liver
Chromium
(Cr)
Meat products,
cheese, whole
grain, milk, eggs,
pepper
Molybdenu
m
Whole grain,
wheat germ, nuts,
legumes, green
leafy vegetable
Water
Human body made up of
55-75% of water.
It forms the basis of blood,
Digestive juices, urine, sweat,
& is contained in lean muscle,
Fat & bones.
Water
As the body cant store water, everyday fresh supplies needed
to make up for losses from lungs, skin, urine and faeces.
The amount of water needed depends upon the individuals
condition, physical exercise, environmental temperature
,humidity, & the food eaten.
RDI of water for male-3.7 lt/day & for female-2.7 lt/day
including water contained in food, beverages & drinking water.
Food gives 0.5-1 lit of water, metabolism of nutrients gives
0.25-0.4 lit water.
Thus male require 2-3 lit of water / day & female require
1-2 lit of water / day of fluid to meet their RDI for water.
10
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