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Harliansyah, Ph.D
Dept. BioMed YARSI University
Objective Contradiction:
large amount O2 consumption ---250ml/min (360L/day)
S ( sigmoid shaped )
I . F: [H+]
pCO2
temperature
a. right shift
b. affinity
2,3- DPG
[H+]
pCO
a. left shift
5. P50:
P50 is the PO2 at the 50% SO2
N. V: N P50 = 26 27 mmHg
I . F: right shift P50
left shift P50
3. Types/Causes/Mechanisms/Features
of hypoxia
The processes of oxygen supplied and
utilization contains:
a. lung intake oxygen
b. Hb carring O2
c. circulation transporting O2
d. cell utilizing O2
Therefore, hypoxia can be divided into four
types .
PO2
2. Hemic hypoxia (isotonic hypoxemia)
mechanisms:
PaO2 CO2 SaO2 inadequate supply O2 to
tissue
Features:
a. PaO2 PvO2
b. CaO2 CaO2
c. CO2max = N
d. SaO2
e. (CaO2 - CvO2)or N
f. central cyanosis
g. Respiratory compensation
Mechanisms :
a. CO2max CO2 afford O2 to tissue
b. CO2max N orbut affinity O2 released
disorder afford O2 to tissue
Mechanisms:
Reduced tissue perfusiona. ischemia hypoxia
b. congestive hypoxia
Features:
a. PaO2 = N
PvO2
b. CaO2 = N CvO2
c. CO2max = N
d. SaO2 = N
e. (CaO2-CvO2)
f. peripheral cyanosis
g. Respiratory compensation or not
Mechanisms:
Disorder of biological oxidation or
oxidative phosphorylation failure to
utilization of oxygen ATP.
Features:
a. PaO2 = N, PvO2
b. CaO2 = N, CvO2
c. CO2max = N
d. SaO2 = N
e. (CaO2-CvO2)
f. No cyanosis
PaO2
SaO2
O2 capacity
CaO2
or N
Hemic hypoxia
Circulatory hypoxia
Histogenic hypoxia
Note: decrease;
increase;
or N
CaO2-CvO2
or N
N normal.
2.circulatory system
a.Cardiac output : tachycardia arrhythmia
myocardial contractility
b.Redistribution of blood To afford blood to
heart and brain
c.Pulmonary vasoconstriction pulmonary
arterial hypertension right heart failure
3.Hemic system
a. Rightward shift of oxyhemoglobin dissociation
curve
b. Increase of red blood cell: erythropoietin(EPO)
5.Cell
Compensation: a. increased ability to use O2
b. anaerobic glycolysis
c. increase of myoglobin
Oxygen toxication:
1. Pulmonary oxygen toxication
2. Cerebral oxygen toxication