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INJURY
PREPARED BY:
INFLAMMATORY RESPONSE
INJURY or INFECTION
LOCAL or SYSTEMIC
PATHOGEN-associated
or DAMAGE-associated
RESTORATION
OF
HOMEOSTASIS
HOST INSULT
MINOR
localized
transient
most cases: beneficial
MAJOR
amplified reaction
systemic inflammation
remote organ damage
multiple organ failure
- 30% of severly injured patients
TRAUMA
leading cause of mortality and
morbidity for individuals under 45
y/o.
THE DETECTION OF
CELLULAR INJURY
LIMIT DAMAGE
ANTIINFLAMMATORY RESPONSE
modulate the proinflammatory phase
direct a return to homeostasis