ObeSense

Monitoring the Consequences of Obesity

Motivations
Obesity is associated with multiple health problems
Cardiovascular diseases
Atrial fibrillation
Hypertension
Obstructive sleep apnea
Diabetes
Certain types of cancer

Has been proven to reduce life expectancy :

10% of premature adult deaths

Is reaching epidemic proportions

Ex : Switzerland : 48.7% overweight, 8.3% obese
7.3% of the total healthcare expenses

Guidelines about identification, evaluation and treatment exist

Those guidelines require long-term monitoring
Such monitoring systems do not exist

Objectives

Answer a clear medical need by joining research in

physiological markers sensors with clinical end-users

Develop innovative and non-invasive sensors
Integrate them into single long-term monitoring systems adapted

to obese patients
Multi-parametric, low-power, allergy-free, comfortable, with on-line feedback.

Innovations in
Sensors (including robustness & cost)
Algorithms (in real-life conditions)
Ultra-low power HW & SW design
Integration into smart textiles
Clinical practice

Central involvement of end-users

Through 3 clinical scenarios

Clinical scenarios

Scenario 1: physical activity & lifestyle

interventions

Supervised by Dr O. Driaz (IRR) and Dr U. Mder

(SFISM) on patients following activity regimen in lab

settings and at home

Scenario 2: hospitalization monitoring

Obesity and atrial fibrillation, hypertension and type-2

diabetes
Supervised by Dr E. Pruvot (CHUV)

Scenario 3: ambulatory monitoring

Obesity and outpatient cardiovascular complications
Supervised by Dr E. Pruvot (CHUV)

Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
New optical fiber belt system (EMPA)

Water vapor permeable

Adjustable in size
is protected from external light
6 have been delivered for validation

Dedicated exploratory platform (CSEM)

6 measurement channels
Isolated DC/DC converter, certified for medical application (IEC
60601-1)
USB battery recharger
Approved by Swissmedic

Technical developments & validations

Sensors, systems and algorithms
Respiratory rate and volume
New optical fiber belt system (EMPA)

Water vapor permeable

Adjustable in size
is protected from external light
6 have been delivered for validation

Dedicated exploratory platform (CSEM)

6 measurement channels
Isolated DC/DC converter, certified for medical application (IEC 60601-1)
USB battery recharger
Approved by Swissmedic

Validation

Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
EIT (EPFL-LTS5 & CSEM) :

Better understanding of the origin of the EIT signal

3D dynamic bio-impedance model from MR data
Confirmation of the feasibility of estimating stroke volume (SV) by EIT
Evidence of the sensitivity to electrode displacement
Optimization of the EIT measurement setup
Clinical validation in preparation
(Swissethics ID: 2015-00203)

Systolic Volume Balance (EPFL-LHTC)

Cardiac output estimation by processing of pressure
waveforms
Comparison with commercial systems (Nexfin)

Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Prediction of the Anaerobic Threshold (AT) from the variability of

different measures (VT, BR, HR)

Prediction of EE from acceleration forces and bio-potentials,
advanced classification algorithm
NIRS oximeter (USZ) : tested in phantoms and humans, and new
Java based mobile app for cell phones and tablets

Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Prediction of the Anaerobic Threshold (AT) from the variability of

different measures (VT, BR, HR)

Prediction of EE from acceleration forces and bio-potentials,
advanced classification algorithm
NIRS oximeter (USZ) : tested in phantoms and humans, and new
Java based mobile app for cell phones and tablets

Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Prediction of the Anaerobic Threshold (AT) from the variability of

different measures (VT, BR, HR)

Prediction of EE from acceleration forces and bio-potentials,
advanced classification algorithm
NIRS oximeter (USZ) : tested in phantoms and humans, and new
Java based mobile app for cell phones and tablets

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Technical developments & validations

Sensors, systems and algorithms
Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Prediction of the Anaerobic Threshold (AT) from the variability of different

measures (VT, BR, HR)

Prediction of EE from acceleration forces and bio-potentials, advanced
classification algorithm
NIRS oximeter (USZ) : tested in phantoms and humans, and new Java
based mobile app for cell phones and tablets
New monitoring device for EE and other parameters (ECG) : CE certified
and tested

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Technical developments & validations

Sensors, systems and algorithms
Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Blood pressure
BP from Multi-channel Photo-Plathysmography (PPG), Electro-Cardiography (ECG),

and Impedance-Cardiography (ICG)

New datalogger
Verified on healthy volunteers
Validation protocol with the CHUV
Safety and conformity test passed
Swissmedic approval for a clinical study obtained in Oct 2015
Ethical Committee approval in December 2015
On-going clinical trial (CHUV & Inselspital)

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Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Blood pressure
Smart ECG t-shirts (EMPA)
Small single electrode with integrated humidification pad
Integrated and validated in smart t-shirts

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Technical developments & validations

Sensors, systems and algorithms
Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Blood pressure
Smart ECG t-shirts (EMPA)
Wireless body sensor network
Completion of the design of the CSEM platform :

Two dedicated microcontrollers

Certified 12-lead ECG frontend
3D accelerometer
Li-Polymer battery
Bluetooth & WiFi
Wireless charger Qi
ISO 13485 -> CE marking for medical devise-Polymer battery

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Technical developments & validations

Sensors, systems and algorithms
Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL-ASPG)
Blood pressure
Smart ECG t-shirts (EMPA)
Wireless body sensor network
ECG Analysis (EPFL-ASPG)
Respiratory rate estimation from ECG
Instantaneous baroreflex estimation from BP
PPG based instantaneous baroreflex sensitivity measurements
Estimating physiological rhythms with a very low time-delay

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Technical developments & validations

Sensors, systems and algorithms

Respiratory rate and volume
Cardiac Output
Energy expenditure (CSEM, USZ, IRR, EPFL

ASPG)
Blood pressure
Smart ECG t-shirts (EMPA)
Wireless body sensor network
ECG Analysis (EPFL-ASPG)

Scientific outcomes
8 journal papers (IEEE, ACM, Sensors, Physiological measurement, )
25 conference papers
8 PhD students

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Clinical scenarios

Scenario 1: physical activity & lifestyle

interventions

Supervised by Dr O. Driaz (IRR) and Dr U. Mder

(SFISM) on patients following activity regimen in lab

settings and at home

Scenario 2: hospitalization monitoring

Obesity and atrial fibrillation, hypertension and type-2

diabetes
Supervised by Dr E. Pruvot (CHUV)

Scenario 3: ambulatory monitoring

Obesity and outpatient cardiovascular complications
Supervised by Dr E. Pruvot (CHUV)

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Platform development versus clinical scenarios

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Scenario I : Physical activity monitoring

Platform WES (activity tracker)

Validation of physiological parameters with

scientific publications (MET model, walking

and running speed and distance)
Validation of ECG quality sufficient for
diagnosis (on going - to be published)
CE marking with medical safety standards
Compatible with off-the-shelf smart textiles
(Polar, Addidas, Victorias secret, etc.)
Ready for industrial transfer

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Scenario II : Blood pressure monitoring

Platform BP (dedicated multisensors)

Target medical CE marking

Approved Swissmedic & Ethics committee
Validation of estimated central blood pressure

against catheter measurements (on-going

clinical trials at the CHUV and at the
Inselspital)
(Almost-)ready for industrial transfer

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Conclusions

ObeSense contributed
A series of methods and devices
Leading edge scientific research
Prototype integration
Focus on the validation
Several fully integrated, validated and
certified
Several on-going clinical validation

studies
Ethical committee approved
On-going data collection and analysis

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