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INTRODUCTIO
N
Systemic immune response leads to activation of
GOALS
METHODS
accordaning BITERN guidelines and general methods recommended
by Cochrane collaboration.
included all clinical trials, investigating dexmedetomidine in patients
with sepsis, severe sepsis, or septic shock
Then searched Medline, Scopus, TRIP and CENTRAL, DART,
OpenGrey, and ProQuestwithout applying any language filter up to
July 15, 2015.
Two of the authors independently reviewed search results for
irrelevant and duplicate studies and extracted data and assessed
methodological quality of the studies
used tabulation to synthesize the findings of the studies and
transformed data into a common rubric and calculated a weighted
treatment effect across studies using Review Manager
Result
founded 124 references in 7 databases, and after
exclusion of irrelevant and duplicate studies, 6 studies
with total number of 242 patients with sepsis
DISCUSSION
CONCLUSION
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