Академический Документы
Профессиональный Документы
Культура Документы
Introduction
Materials and Method
Results and Discussion
Conclusion
Curcumin
Curcumin (diferuloylmethane) is an
active ingredient of turmeric isolated
from the roots of Curcuma longa.
It is commonly used as spices and
traditional drink (Jamu)
What is the
objective?
MRS
A
P.
aeruginosa
ESBL
positive K.
pneumoniae
& E. coli
MDR A.
baumannii
High dose of
curcumin up to 8
grams/day DO
NOT exhibit any
toxic effects in
human health
Introduction
Materials and Method
Results and Discussion
Conclusion
Initial citation
lists from all
databases by
key words
(n=1610)
n=1426 excluded: not
an original research
article, not fitting key
terms of inclusion
criteria
Google
Scholar
Initial
screening
of
citations
n=171 excluded: title
(n=184)
not fitting key terms
of inclusion criteria,
only explained
curcumins effect as
general
Scienc
e
Direct
Secondary
screening of
citations
from
n=3 excluded: do not
abstracts
(n=13)provide enough data,
using ultrasound and
photodynamic therapy,
and requires purchase
Full text
journals
that
were
analyzed
Introduction
Materials and Method
Results and Discussion
Conclusion
Figure 4 Results of
curcumin in levels of
Catalase (A and C),
SOD (B and D), and
sensitivity to H202 (E)
Imipenem
MIC
(g/mL)
Imp/Curcu
min MIC
(g/mL)
4
64
1
1
Decrease in
MIC
(number of
dilution)
2
7
8
8
8
4
8
16
4
4
4
0,5
1
1
1
1
1
2
0,5
1
4
3
3
2
3
4
1
3
2
AB292
Introduction
Materials and Method
Results and Discussion
Conclusion
Thank You!
References
1.
Lakshmikantha M, Asthanaashish, Molly M. Antimicrobial Activity of Curcuma Longa Extracts on MethicillinResistant Staphylococcus aureus (MRSA). Journal of Advance Researches in Biological Sciences, 2014, Vol. 6
(3&4) 213-216.
2.
Mun SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, et al. Synergistic antibacterial effect of curcumin
against methicillin-resistant Staphylococcus aureus. J Phymed. 2013; 20(89): 714718.
3.
Mun SH, Kim SB, Kong R, et al. Curcumin Reverse Methicillin Resistance in Staphylococcus aureus. Molecules.
2014, 19, 18283-18295; doi:10.3390/molecules191118283.
4.
Sethupathy S, Prasath KG, Ananthi S, Mahalingam S, Balan SY, Pandian SK. Proteomic analysis reveals
modulation of iron homeostasis and oxidative stress response in Pseudomonas aeruginosa PAO1 by curcumin
inhibiting quorum sensing regulated virulence factors and biofilm production. Journal of Proteomics.
Forthcoming 2016. doi: 10.1016/j.jprot.2016.04.019
5.
Gunes H, Dogan M, Gumus A, Mutlu R, Topkaya AR. Investigation of synergistic effect of curcumin with some
antibiotics in extended spectrum beta lactamase positive or negative Escherichia coli and Klebsiella
pneumoniae isolates. Acta Mediterania. 2013, 29: 761.
6.
Betts JW, Wareham DW. In vitro activity of curcumin in combination with epigallocatechin gallate (EGCG)
versus multidrug-resistant Acinetobacter baumannii. BMC Microbiology. 2014, 14:172.
7.
Tyagi P, Singh M, Kumari H, Kumari A, Mukhopadhyay K. Bactericidal Activity of Curcumin I Is Associated with
Damaging of Bacterial Membrane. PLoS ONE. 2015. 10(3): e0121313. doi:10.1371/journal.pone.0121313.
8.
Gunes H, Gulen D, Gumus A, Mutlu R, Tas T, Topkaya AR. Antibacterial effects of curcumin: an in vitro
minimum inhibitory concentration study. Toxicol Ind Health. 2013. DOI: 10.1177/0748233713498458.