PIGEMENTE

D CELLULAR
NEVUS
SUMMAIRA SARWAR
ROLL NO:11

NEVUS:
A benign, exophytic, usually
pigmented, congenital lesion of
the skin or mucosa composed of
focal collections of rounded
melanocytes (nevus cells).
The term nevus commonly
used for mole.
Nevi mostly occur on skin,
occasionally occur on mucous
membrane.
Its also called birthmark.

Classification:

Intradermal (mucosal)

Junctional

Compound

Macular form also called

Blue nevus

Epithelioid or Spitz

INTRAMUCOSL
NEVUS:
It is also known as
INTRADERMAL nevus.

CLINICAL FEATURES:

The lesion grows slowly.

It is generally less then 1 cm
in diameter.
Intradermal nevus occurs in
young patients and is one of
common skin lesions.
On skin it is raised or flat.
It is tan or dark brown.
It will often contain more hair
than surrounding normal
skin.

Intramucosal nevus occurs in

oral cavity mostly on the Hard
palate or Gingiva.
Its an asymptomatic.
Pigmented.
Brown to black.
Slighted elevated papule or
flat macule.

HISTOPATHOLOGY:
It is characterized by nests,
cords or sheets of nevus cell
confined to connective
tissue.
Cells of nevus may be
epithelioid, lymphocyte like,
spindle or multinucleated
types.
Mitotic figures are usually
absent.
One of features of nevus is
presence of fibrous

TREATMENT:
As a general rule all solitary
pigmented papules or
nodules of the oral cavity
should be excised. Once
excised nevi do not tend to
recur.

JUNCTIONAL NEVUS:

CLINICAL FEATURES:
It is benign.
Brown to black lesion.
Occurs primarily on the
skin and occasionally on
oral mucosa.
Within oral cavity it
usually appears as a
pigmented macular lesion
on the hard palate or
gingiva.

HISTOPATHOLOGY:
It is characterized by the
presence of nevus cell nests in
the basilar region of
epithelium.
No nevus cells found in
surround connective tissue.
Careful examination is required
because similar type of focal
proliferation of melanocytes
(junctional cavity) occurs in
melanoma.
It is important to note it can

TREATMENT:
It should be excised and
submitted to histopathological
examination. Once excised, a
junctional nevus does not
tend to recur.

COMPOUND NEVUS:

 It has the combined

characteristics of the
intramucosal nevus and
junctional nevus.
Exhibiting nevus cells in
the basal region of the
epithelium and the
adjacent connective
tissue.

CLINICAL FEATURES:

Compound nevus is far

more common then other
nevi.
In oral cavity it tends to
occur as pigmented
papule or macule.
It occurs on hard palate
or gingiva.

TREATMENT:
The nevus is treated by an
excisional biopsy that
serves as a diagnostic and

BLUE
NEVUS:

CLINICAL FEATURES:
The blue nevus in benign
pigmented lesion that
presents as a dark blue
dome-shaped papule or as a
flat macule on the skin or
mucosa.
It occurs most commonly on
the hard palate.

HISTOPATHOLOGY:
In blue nevus pigmentproducing cells are spindled
and fusiform dendritic cells.
Cells are confined to the
connective tissue.
They are separated and
parallel to the normal
overlying epithelium.
Macrophages often present
among dendritic cells.
They have no tendency to
transform into malignant

TREATMENT:
Excisional biopsy is
performed, which is also
serves as the definitive
treatment for this lesion.

EPITHELIOID
NEVUS:

 It is also called Spitz nevus

and formerly called a benign
juvenile melanoma.

CLINICAL FEATURES:
It presents as a solitary small
pink to reddish-brown papule.
It occurs on skin of face and
extremities of children.

HISTOPATHOLOGY:
It is usually composed of
spindle shaped and large
epithelioid nevus cells with
abundant cytoplasm.
It is relatively circumscribed
nests located at or near
dermal and epidermal
interface.
It is multinucleated.
Its size is 5 to 6 mm in
diameter.

TREATMENT:
Conservative excision of the
entire lesion is curative.

QUESTIONS?
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