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Digestive Functions
Ingestion
intake of food
Digestion
breakdown of molecules
Absorption
uptake nutrients into blood/lymph
Defecation
elimination of undigested material
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Stages of Digestion
Mechanical digestion
physical breakdown of food into smaller particles
teeth and churning action of stomach and intestines
Chemical digestion
series of hydrolysis reactions that break
macromolecules into their monomers
enzymes from saliva, stomach, pancreas and
intestines
results
polysaccharides into monosaccharides
proteins into amino acids
fats into glycerol and fatty acids
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Digestive Processes
Motility
muscular contractions that break up food, mix
it with enzymes and move it along
Secretion
digestive enzymes and hormones
Membrane transport
absorption of nutrients
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Accessory
organs
teeth, tongue,
liver, gallbladder,
pancreas,
salivary glands
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Submucosa
Muscularis externa
inner circular layer
outer longitudinal layer
Adventitia or Serosa
areolar tissue or mesothelium
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myenteric plexus
controls peristalsis
contractions of muscularis externa
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Relationship to Peritoneum
Only duodenum, pancreas and parts of
large intestine are retroperitoneal
Dorsal mesentery suspends GI tract and
forms serosa (visceral peritoneum) of
stomach and intestines
Ventral mesentery forms lesser and greater
omentum
lacy layer of connective tissue that contains
lymph nodes, lymphatic vessels, blood vessels
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Hormones
messengers diffuse into bloodstream, distant
targets
Paracrine secretions
messengers diffuse to nearby target cells
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Dentition
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Tooth Structure
Periodontal ligament is
modified periosteum
anchors into alveolus
Gingiva or gums
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Mastication or Chewing
Breaks food into smaller pieces to be
swallowed
surface area exposed to digestive enzymes
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Saliva
Functions of saliva
moisten, begin starch and fat digestion, cleanse
teeth, inhibit bacteria, bind food together into bolus
pH of 6.8 to 7.0
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Salivary Glands
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Salivation
Total of 1 to 1.5 L of saliva per day
Cells filter water from blood and add other
substances
Food stimulates receptors that signal salivatory
nuclei in medulla and pons
parasympathetic stimulation salivary glands produce
thin saliva, rich in enzymes
sympathetic stimulation produce less abundant,
thicker saliva, with more mucus
Pharynx
Skeletal muscle
deep layer longitudinal orientation
superficial layer circular orientation
superior, middle and inferior pharyngeal
constrictors
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Esophagus
Straight muscular tube 25-30 cm long
nonkeratinized stratified squamous epithelium
esophageal glands in submucosa
skeletal muscle in upper part and smooth in bottom
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Swallowing
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Swallowing (Deglutition)
Series of muscular contractions coordinated by
center in medulla and pons
motor signals from cranial nerves V, VII, IX and XII
Buccal phase
tongue collects food and pushes it back into
oropharynx
Pharyngeal-esophageal phase
soft palate rises and blocks nasopharynx
infrahyoid muscles lift larynx; epiglottis folded back
pharyngeal constrictors push bolus down esophagus
liquids in 2 seconds -- food bolus may take 8 seconds
lower esophageal sphincter relaxes
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Stomach
Mechanically breaks up food, liquifies
food and begins chemical digestion of
protein and fat
resulting soupy mixture is called chyme
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Mucosa
simple columnar glandular epithelium
lamina propria is filled with tubular glands (gastric pits)
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Gastric Gland
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Parietal cells
secrete HCl acid and intrinsic factor
Chief cells
secrete pepsinogen
chymosin and lipase in infancy
Enteroendocrine cells
secrete hormones and paracrine
messengers
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Gastric Secretions
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Chemical Messengers
Many produced by enteroendocrine cells
hormones enter blood distant cells
paracrine secretions neighboring cells
Gut-brain peptides
signaling molecules produced in digestive
tract and CNS
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Gastric Motility
Swallowing center signals stomach to relax
Food stretches stomach activating a receptiverelaxation response
resists stretching briefly, but relaxes to hold more food
Vomiting
Induced by
excessive stretching of stomach,
psychological stimuli or chemical irritants
(bacterial toxins)
vomiting
when abdominal contraction forces upper
esophageal sphincter to open
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Gastric phase
activated by presence of food or semidigested
protein
by stretch or in pH
secretion stimulated by
ACh (from parasympathetic fibers), histamine (from gastric
enteroendocrine cells) and gastrin (from pyloric G cells)
receptors on parietal and chief cells
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Other enzymes
amylase
lipase
ribonuclease and
deoxyribonuclease
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Activation of Zymogens
Small Intestine
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Small Intestine
Duodenum curves around head of pancreas
(10 in.)
Intestinal Crypts
Pores opening between villi lead
to intestinal crypts
absorptive cells, goblet cells and at
base, rapidly dividing cells
life span of 3-6 days as migrate up to
surface and get sloughed off and
digested
Intestinal Villi
Villi of Jejunum
Histology of duodenum
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Intestinal Motility
1. Mixes chyme with intestinal juice, bile and
pancreatic juice
2. Churns chyme to increase contact with mucosa
for absorption and digestion
3. Moves residue towards large intestine
segmentation
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Peristalsis
Gradual movement of
contents towards
colon
Begins after
absorption occurs
Migrating motor
complex controls
waves of contraction
second wave begins
distal to where first
wave began
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Carbohydrate Absorption
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Water Balance
Digestive tract receives about 9 L of water/day
.7 L in food, 1.6 L in drink, 6.7 L in secretions
8 L is absorbed by small intestine and 0.8 L by large
intestine
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Microscopic Anatomy
Mucosa - simple columnar epithelium
anal canal has stratified squamous epithelium
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Flatus (gas)
average person produces 500 mL per day
most is swallowed air but hydrogen sulfide,
indole and skatole produce odor
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Defecation
Stretching of the rectum stimulates defecation
intrinsic defecation reflex via the myenteric plexus
causes muscularis to contract and internal sphincter to relax
relatively weak contractions
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