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Introduction
Two types of virus:
DNA and RNA virus
Life cycle of DNA virus:
Acyclovir
Mechanism of action:
Step 1: activation
Acyclovir
Mechanism of action
Step 2: incorporation into growing DNA
chain
Acyclovir
Dosing regimen:
- Primary HSV infection: 3 x 400 mg (7-10 days)
- Recurrent genital HSV: 3 x 400 mg (5 days)
Or 3 x 800 mg (2 days)
- Immunocompromised: 5 mg/kgBW q8h IV (7 days)
Or 5 x 400 mg (14-21 days)
- Encephalitis 10 mg/kgBW q8h IV (14-21 days)
- Suppression therapy:
2 x 400 mg OR 1 x 800 mg
Preparations: tablets 200 and 400 mg
Acyclovir
Common side effects:
- Nephropathy / nephritis
- Lethargy
- Tremors
- Confusion
- Seizure
- Rash
- Drug eruption
Acyclovir is generally well-tolerated, and very rarely cause
side effect.
Valacyclovir
Valacyclovir
Dosing regimen:
- Primary HSV infection:
- Recurrent genital HSV:
- Immunocompromised:
- Suppression therapy:
2
2
2
1
x
x
x
x
Famcyclovir
Famcyclovir
Dosing regimen:
- Primary HSV infection:
- Recurrent genital HSV:
Or 2 x 1000 mg (1 day)
- Immunocompromised:
- Suppression therapy:
Foscarnet
Lamivudine:
Drug eruption
Paronychia
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