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Protein malnutrition
Embolization
- Thrombi may dislodges and travel to other sites in the
vasculature
Dissolution
- Thrombi may be removed by fibrinolytic activity.
- Activation of fibrinolytic pathways can lead to rapid
shrinkage & even total lyses of recent thrombi in
contrast older thrombi undergo extensive fibrin
polymerization renders the thrombus substantially more
resistant to proteolysis and lyses is ineffectual rather it
tends to become organize
Organization and recanalization
- Organization refers to the in growth of endothelial cells,
smooth muscle cells, and fibroblasts into fibrin rich
thrombus
- Organization accompanied by the formation of
capillary channels across the thrombus, re establishing
lumen continuity to some extent. This is known as
recanalization
Clinical correlations
Thrombi are significant clinically in that:
- They cause obstruction of arteries and veins
- They are possible source of emboli
Venous Thrombosis (Phlebothrombosis)
- Venous thrombosis affects veins of the lower extremity in 90% of
cases