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WISUDAWAN
DEPART. OF FARMACOLOGY,
MEDICAL FACULTY, MOSLEM
UNIVERSITY
ANTIVIRAL DRUGS
Number of drugs available: limited
Difficult to obtain selective toxicity to virus:
replication of virus is the normal synthetic
process
of the cell
Several virus-specific replication steps the site
of action of effective antiviral drugs.
Antiviral drugs are relatively ineffective: many cycle
of viral replication occur during the incubation time.
Some viruses become latent within the cell: no
current antiviral drugs can eradicate them.
Emergence of drug resistance viral mutans.
MODE OF ACTIONS
Inhibition of Viral Nucleic Acid Synthesis
Inhibition of Cleavage of Precursor
Polypetides
Inhibition of Viral Protein Synthesis
Inhibition of Release of Virus
A. Nucleoside Inhibitors
Inhibit the DNA synthesis by the reverse transcriptase of HIV
1. Azidothymidine: a nucleoside analogue that causes chain
termination during DNA synthesis: it has an acido-group in place
of th hydroxyl group on the ribose.