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Learning Objectives
Influenced by
Dates drug first used in humans
Penetration into local marketplace (changes in
cost, regulatory approval)
Evolution of National TB Program (NTP) regimens
Introduction of free-of-charge Rx
Availability as OTCs
Anti-TB Drugs
First-Line Second-Line
Drug Frequency
Isoniazid 1/1,000,000
Pyrazinamide 1/1,000,000
Streptomycin 1/1,000,000
Ethambutol 1/100,000
Rifampin 1/100,000,000
INH
INH INH
RIF