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Lecture 1
Biochemical Engineering
Review of
Thermodynamics
System any matter
identified for
investigation
Surroundings the
remainder of the universe
Boundary separates
system from surroundings
May be real and tangible
or virtual and nominal
Types of System
Process causes changes in the system or
surroundings
Equilibrium
Describes a system in which all opposing forces
are counter-balanced, leading to insignificant
changes in the properties of the system
Law of Conservation of Mass
Integral Balance
Used for batch, semi-batch and fed-batch
Based on the quantity or mass, usualy over a
specified time period
Simplified General Mass Balance: the
Steady-state
At steady-state, does mass in = mass
out?
Material With reaction Without reaction
Total mass Yes Yes
Total moles No Yes
Mass of a molecular specie No Yes
Moles of a molecular specie No Yes
Mass of an atomic specie Yes Yes
Moles of an atomic specie Yes Yes
Procedure for material balance calculation
cells is filtered using a continuous rotary vacuum filter. Slurry 1. Draw a clear
process flow
is fed to the filter at the rate of 120 kg/h; 1 kg slurry contains 60 diagram
g cell solids. To improve filtration rates, particles of
2. Select a set of units
diatomaceous aerth filter aid are added at a rate of 10 kg/h. the and state it clearly