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CIRCULATORY
CIRCULATORY SYSTEMS
SYSTEMS
Consist of 2 systems : 1,2
Heart : pump
4 chambers :
R/L atriums
R/L ventricles
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4 Valves :
Mitral valve
Tricuspid valve
Aortic valve
Pulmonary semilunar valve
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Heart Wall : 1, 2
Endocardium
Myocardium
Epicardium
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I. Endocardium
Inner layer of atriums & ventricles2
Homologous with tunica intima of
blood vessels
Consist of : 1, 2
1.Endothelium :
Simple squamous epithelium
Junctions :
Tight/occluding junctions
Gap junctions
2. Subendocardial layer :
Loose connective tissue
Contain veins, nerves,
Purkinje cells (branches of
impulse conducting system of
heart
Connected to myocardium
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II. Myocardium Thick
e st o n
ventr
icles 2
Thickest tunics
cardiac muscle cells
1. Conducting Impluse
Fiber
2. Contractile
Fiber 8
1. Conducting Impulse Fiber
Conduction system of
heart: 2, 3
Modification of cardiac
muscle cells
Generate a rythmic stimulus
Consist of :
1. 2 node in atrium wall:
Sinoatrial node/SA node
Atrioventricular node/AV
node
2. AV bundle branches of
AV node
3. Purkinje fibers
branches of AV bundle 9
Purkinje fibers : 2, 3
Branches of AV Bundle
Located at subendocardial
Distinctive appearance with
ordinary cardiac muscle :
Larger & contain more
cytoplasm
Less myofibril
Rich in mitochondria &
glycogen
1 or 2 central nuclei
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2. Contractile
Fiber
Elongated, cylindrical & branching
fiber
Each fiber contains only 1 or 2 nuclei,
centrally placed
Cross striations similar to skeletal
muscle (A/I/H band & M/Z line)
Sarcoplasm contain numerous large
mitochondria
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Special junctions at the end
of two cardiac fiber
3 junctions :
1.Fascia adherens
2.Macula adherens
(desmosome)
3.Gap junctions
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Intercalated Disc with light microscope
dark lines crossed the cardiac fiber
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III. Epicardium
Homologue to tunica
adventitia in blood vessels3
Outermost layer of heart wall3
Consist of : 1, 2
1. Pericardium viceral
mesothelium (simple
squamous epithelium)
2. Subepicardial layer
loose connective tissue
with coronary vessels,
nerves & ganglia
3. Pericardium parietal:
mesothelium & conn.
tissue
Space between pericardium
contain serous liquid for
lubricating 14
BLOOD
BLOOD VESSELS
VESSELS
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BLOOD
BLOOD VESSELS
VESSELS
Differ in size, distribution & function but have similarity in
several feature 2, 3
Wall divided into : 1, 2, 3
1. Tunica Intima :
Endothelium : simple squamous epthelium, rest on
basal lamina
Provide smooth surface of blood vessel
Secreting type I, IV & V collagen, lamin,
endothelin, nitric oxide, von Willebrand factor.
Posses membrane bound enzyme such as
angiostensin converting enzyme (ACE)
Subendothelium loose conn. tissue, few scattered
smooth muscle
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2. Tunica Media:
Equivalent to myocardium
Most variable layer in size &
structure
Contain variable amount of
smooth muscle & elastic
tissue depend on blood
vessel function
3. Tunica Adventitia:
Correspond to epicardium
lack mesothelial cells
Varies in thicknes
Mostly composed of
fibroblast, type I collagen
fiber & elastic fiber
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Blood Vessel Wall Composition
ELASTIC TISSUE
LARGE ARTERIES MUSCLE
SMALL ARTERIES
MEAN PRESSURE
ARTERIOLES
CAPILLARIES
VENULES &VEINS
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CLASSIFICATION OF BLOOD VESSELS
ARTERIES
Elastic arteries / conducting arteries
Arteriole
VEIN
Large vein
Venule
CAPILLARIES
Continuous capillaries
Fenestrated capillaries
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Sinusoidal capillaries
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ARTERIE
ARTERIE
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A.
A. ELASTIC
ELASTIC ARTERIE
ARTERIE
Aorta, Iliaca Communis,
Pulmonaris, Brachiocephalic,
Subclavia, Carotid Comm. 2
Yellow wall coz abundance of
elastin in T. media
Tunica Intima : (1, 2)
Thick thicker than T.
intima A. Muscularis
Endothelial cells
Tunika Intima Weibel-Palade bodies
von Willebrand factor
(stored only in arteries)
Membran elastica interna
incomplete
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Thickest layer from 2 other tunica
40-70 layer of elastic membran
Smooth muscle (+)
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T. Adventitia :
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B. MEDIUM & SMALL ARTERIE
Endothelial cells Weibel-Palade bodies
von Willebrand factor
Membran elastica interna(+)
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Smooth muscle layer:
Muscular A. : thick up to 40 layers
Small A. thin
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Muscular A. as thick as T. media
consist of colagen & elastin fiber
Membrana elastica eksterna(+)
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Thin T. Adventitia
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C. ARTERIOLE
Generally diameter < 0,5 mm & narrow lumen
T. Intima :
Sub endothelial layer very thin
M. Elastica Interna (-)
T. Media : Smooth Muscle 1-2 layer
T. Adventitia :
Very thin
M. elastica eksterna (-)
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Metaarteriole :
Branching of arteriole into capillaries 2
Constriction help in regulate blood flow in
capillaries 1, 2
Discontinue smooth muscle 1
Smooth muscle as pre capillary sphincter
control blood flow into capillary bed 3
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Specialized Sensory Structure in
Arteries
3 types: carotid sinus, carotid
body, aortic body monitor
blood pressure & blood
composition essential
input to brain for controlling
heart beat, respiration & BP
Carotid sinus :
Baroreceptor wall of
carotid internal A.
T. adventitia thinner &
heavily endowed with sensory
nerve from cranial nerve IX
T. Media relatively thinner
permit to be distended
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Carotid body:
Chemoreceptor in bifurcation of common A.
Composed of small pale staining cells in conn.
Tissue 2 type : glomus (type I) cells & sheath
(type II) cells
Glomus cells : large nucleus, dense cored vesicles,
cell process contact with other glomus cell &
capillary endothelial cell
Sheath cells : more long & complex process,
irregular nuclei
Aortic body: structure similar to carotid body
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V
VEE II N
N
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VEIN
VEIN
Classification: 1, 2
A. Large Vein
B. Medium & small veins
C. Venule
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A. LARGE VEINS
Similar to medium vein
Endotelium
Subendotel layer thin
T
hin
t. m m
S m e d i a o s t
oot lar
hm ge
u sc vei
le nw
&c ith
onn out
. ti
ss u
e
40
Thickest and well develop
Smooth muscle & conn. Tissue with
colagen & elastin fiber
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2 s e m i
lunar fo
C o m p o ld of T.
sed of c in t
N u m e r onn. tiss ima proj ect t
o us in li ue & lin o lumen
mb ed by en
do theliu
m
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C. VENULE
T. Intima : 1, 2
Thin & continue endothelium
Thin basal lamina with
pericytes
T. Media : 3
Sparse conn. Tissue & few
smooth muscle cell
T. adventitia :(1, 2)
Thin
Colagen & fibroblast
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CAPILLARIES
CAPILLARIES
Smallest blood vessel 1, 3
General structure : 2, 3
T. Intima single layer
of endothelium
Pericytes located along
outside contractile
function
Classification:1, 2
A. Continue/somatic
capillaries
B. Fenestrated/perforate
d capillaries
C. Sinusoid
Slow blood flow (0,3
mm/detik, aorta = 320
mm/detik
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A. CONTINUE CAPILLARY
Found in Conn. Tissue, muscle,
CNS 1, 2
Endothelium continue fasciae
occludentes 3 prevent passage
many molecules
Form Blood Brain Barrier
permeable only to certain
substances
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B. FENESTRATED CAPILLARY
Similar to continue but have
pores1, 3
Found in : kidney, intestine,
endocrine gland
Fenestrae :
Covered with a pore diaphragm1
Pore diaphragm not found in
glomerulus1
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C. SINUSOID
Structure : 1, 2, 3
Tortouos path, greatly enlarged diameter
slows the circulation of blood
Endothelium cells form discontinue layer
Discontinue basal lamina
Many fenestrae lack with diaphragm
Found in heart & hematopoetic
organs1, 2
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ARTERIOLE,
ARTERIOLE, VENULE
VENULE &
& CAPILLARIE
CAPILLARIE
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LYMPH
LYMPH VASCULAR
VASCULAR SYSTEM
SYSTEM
Return extracellular liquid
to bloodstream1, 2 One
direction
Present in throughout body
except CNS & other few
area
Blind end lymphatic
capillarieslymphatic
vessel lymphatic ducts 1,
2, 3
A. Lymphatic capillaries :
single layer of attenuated
endothelial cells with
incomplete basal lamina
blind end
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B. Lymphatic vessel :
Closely spaced valves1
Large lymphatic vessel
resemble small veins1
Lumina larger, walls thinner
Endothelium (+)
Smooth muscle (+), collagen
& elastic fiber(+)
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C. 2 Lymphatic ducts :
Consist of : 1, 2
Ductus Thoracicus
Ductus Limphaticus Dexter
Similar to large veins 1, 2
Vasa vasorum & rich in vascular network 1
Walls : 2
T. Intima : Endothel & subendothel (+), Lamina elastica
Interna (+)
T. Media : smooth muscle > vein
T. Adventitia : undevelop
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REFERENCES :
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QUIZ
QUIZ
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1.Small Arteri.
2.Large Arteri.
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