Hypertensive drug adjustment

on Renal failure
 Dosimetry in renal failure
Initial assessment
History of previous drug intolerance or toxicity
Patient current medication list
Height and body weight information
An assessment of axtracelluler fluid volume
Identification of extra renal disease
 Dosimetry in renal failure
Calculate creatinin clearance
Body mass and age affect serum creatinin
concentrations and clearance can be estimated
by Cockcroft and Gault estimation:

In women, this result should be multiplied by

0.85.
 Dosimetry in renal failure
Choose a loading dose

Vd = Volume distribution (L/Kg)

IBW = Ideal body weight (Kg)
Cp = Concentration of plasma (mg/L)
 Dosimetry in renal failure
Choose a maintenance dose