Академический Документы
Профессиональный Документы
Культура Документы
CYTOSKELETON
Carmen Lpez M.D.
Hematologist
Introduction
Cell are the basic structural and functional Cytoplasm
units of all multicellular organisms
They use the same kinds of molecules to engage in
contraction, and they duplicate their genetic material in the
same manner.
Nucleus
Amphipathic character:
The fatty acid chains of the
lipid molecules face each
other making the inner
potion of the membrane
hydrophobic and the
surface is hydrophilic.
Microdomains of the plasma membrane, known as lipid rafts, control the movement
and distribution of proteins within the lipid bilayer.
Lipid rafts: is a localized regions within the plasma membrane contain high
concentrations of cholesterol and glycoesphingolipids
Is thicker and exhibits less fluidity than the surrounding.
And contain a variety of integral and peripheral membrane proteins involved in cell
signaling (Signaling platforms).
Plasma Membrane
Carrier Transfer small, water soluble molecules, they are highly selective.
Some carrier proteins such as the Na+/K+ pump or H+ pump,
require energy for active transport of molecules against their
proteins
concentration gradient.
Other carrier proteins such as glucose do not require energy and
participate in passive transport.
proteins
can be regulate by membrane potentials, neurotransmitters or
mechanical stress.
Membrane transport
Vesicular transport maintains the integrity of the plasma membrane and also
provides for the transfer of the molecules between different cellular compartments.
Forming the vesicle from the membrane or fusion of vesicles with the membrane.
Microtubules measure 20 to
Microtubules are elongated 25 nm in diameter
polymeric structures
The wall is 5 nm thick
composed of equal parts of
-tubulin and Btubulin Tubulin dimer have a
molecular weight 110 kDa.
Microtubules
The dimers polymerize in an end to
end fashion, head to tail with the
molecule of one dimer bound to
the molecule of the next dimer in
a repeating pattern.
Protofilament, longitudinal
contacts between dimers link them
into a linear structure.
Microtubules
Microtubules grown from
Polymerization of tubulin Each tubulin molecules
tubulin rings within the dimers requires GTP + binds GTP before it is
microtubule-organizing Mg2+ incorporated
center (MTOC)
Each microtubule
possesses a minus and at some point GTP is GTP-tubulin complex is
(nongrowing) end (- hydrolyzed to GDP then polymerized
tubulin)
According to new nomenclature, keratins are divided into three expression groups:
keratins of simple epithelia
keratins of stratified epithelia
and structural keratins, also called hard keratins.
The latest are found in skin appendages such as hair and nails.
Intermediate Filaments
is the most abundant intermediate
Vimentin filament found in all mesoderm-
derived cells, including fibroblasts.
with the exception of desmin, preferentially form homopolymeric filaments containing only one
type of intermediate protein.
Intermediate Filaments
Form heterodimer that contains one NF-L + one of the others. All three proteins form
neurofilamentsthat extend from the cell body into the ends of axons and dendrites.
Intermediate Filaments
Class 5. Lamins, specifically nuclear lamins, form a network-like structure that is associated with
the nuclear envelope.
Lamins are represented by two types of proteins, lamin A and lamin B.
are located within the nucleoplasm of almost all differentiated cells in the body
they function in chromatin organization, gene expression, nuclear architecture, and cell signaling
and provide an essential link between the nucleoskeleton and cytoskeleton of the cell.