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FAILURE
By Maritza I. Garcia-Duran & Joao Mc-Oneil
Internal Medicine
06/21/2010
ACUTE KINEY FAILURE A.K.A. ACUTE
KIDNEY INJURY (AKI)
REVERSIBLE
CAUSES
OTHER SIGNS AND SYMPTOMS OF AKI
f/b generalized swelling, d/t waste products build
in the blood.
Met. Acidosis
Arrhythmias d/t hyperkalemia. Including v-tach
and v-fib
Encephalopathy = altered thinking and
pericarditis d/t uremia and low serum calcium
Anemia d/t decreased EPO production
Hypertension d/t inc fluid deposited in lung causing
CHF
Tachypnea
DIAGNOSIS
Metabolic acidosis
Hyperkalemia
pulmonary edema
end-stage renal failure
requiring lifelong dialysis or a
kidney transplant.
QUESTION
For each of the following questions, choose the
pathophysiologic mechanism of reduced
glomerular filtration rate (GFR).
A. Acute tubular necrosis
C. Glomerulonephritis
D. Hypovolemia
IRREVERSIBLE
Causes
diabetic nephropathy,
hypertension
glomerulonephritis.
HIV nephropathy.
PCKD
CLASSIFICATION
A.Hypercalcemia
B.Hypophosphatemia
C.Osteomalacia
D.Vitamin D excess
E.Hypoparathyroidism
ANSWER
C. Osteomalacia
Chronic renal failure treated with hemodialysis results
in predictable metabolic abnormalities. The kidneys fail
to excrete phosphate, leading to hyperphosphatemia
and fail to excrete phosphate, leading to
hyperphosphatemia, and fail to syntehsize 1,25
(OH)2D3. Vitamin D deficiency causes impaired
interstitial calcium absorption. Phosphate retention,
defective intestinal absorption, and skeletal resistance
to parathyroid hormone all results in hypocalcemia.
Hypocalcemia causes secondary hyperparathyroidism,
and the excess PTH production worsens the
hyperphosphatemia by increasing phosphorus release
from bone. These derangements impair collagen
synthesis and maturation, resulting in skeletal
abnormalities collectively reffered to as renal
osteodystrophy. Osteomalacia, osteosclerosis, and
osteitis fribrosa cystica may all be seen. (Kasper et al.,
2005, pp. 1656-1657).
QUESTION #2
A. Tetracycline.
B. Gentamicin
C. Erythromycin
D. Nafcillin
E. Choramphenicol.
ANSWER
B. Gentamicin
Many drug require dosage modifications in chronic
renal insufficiency. Bioavailability, distribution, action,
and elimination of drugs all may altered. Drug that are
nephrotoxic may be contraindicated or used only with
extreme care in renal insuficiency. The amino-
glycosides, vancomycin, ampicillin, most cephalosporins,
methicillin, penicillin G, sulfonamides, and
trimethoprim all should be given in reduced dosage to
patients with chronic renal failure. The aminoglycosides
and vancomycin can be nephrotoxic and should be used
with caution in renal insufficiency. The small group of
antibiotics not needing dosage modification includes
chloramphenicol, erythromycin, the isoxazolyl
penicillins (nafcilllin and oxacillin) and moxifloxacin.
(Kasper et al., 2005, p. 1662, 19).
What is man but an ingenious
machine designed to turn with
infinite artfulness, the red
wine of shiraz into urine !
Isak Denison