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management in stroke
Author :
Ritvij Bowry, MD
Digvijaya D. Navalkele, MD
MPH Nicole R. Gonzales, MD
Introduction
The relationship between hypertension
and stroke is dynamic and multi
faceted. Be it in the context of
managing ischemic or hemorrhagic
stroke, selecting an appropriate
bloodpressure (BP) agent involves
integration of several issues that must
be recognized in order to formulate an
effective strategy for BP control.
Blood pressure, ischemic stroke,
and thrombolysis
O More than 60% of patients with acute ischemic
stroke (AIS) elevated BP (within 1 hour of
symptom onset)
O Elevated BP thrombolytic eligibility and has been
associated with delay in administration of IV tissue
plasminogen activator (IV tPA).
O Timely management of elevated BP is crucial when
patients are otherwise eligible for IV tPA
O The need for prethrombolytic BP goal is 185/110
mmHg
O If BP goal not achieved tPA may be even
withheld Poorer clinical outcome in SICH
O To reduce BP proficiently, agents and continous
infusions could be used
O Aggresively reducing BP to <185/110mmHg with BP
agents safe for patients eligible for TPA (within 3
hours of symptoms)
O If intra arterial (IA) lysis with tPA is planned BP
target <180/100mmHg
O IA recanalization as monotherapy reduce 10-20%
O IA + tPA <180/105mmHg target of BP
O Systolic BP >140mmHg targeted, if below the
treshold it will lead into a poor neurologic outcome
O If complete recanalization is achieved Goal BP
120-140mmHg (lowering the risk of reperfusion
hemorrhage)
O It is reasonable to maintain SBP up top
185mmHg for 24-48 hours (to augment
collateral blood flow & clear emboli from
istal vasculature)
BP must be optimized to
minimize the rate of
symptomatic intracranial
hemorrhage, reperfusion injury,
and promote adequate cerebral
perfusion
BP and Ischemic Stroke When
Thrombolysis is not an option
O If BP 220/120mmHg reducing 15%
is the reccomendation
O Antihypertensive therapy is routinely initiated
within 24 hours after AIS
O BP control beyond 15 hours from onset of an
IS may have a little effect on the clinical
outcome
O A management strategy must ensure a
patients neurologic stability
Specific Goals for Specific
Conditions
O Small Vessel disease
Goal of SBP <130mmHg vs range of 130-
140mmHg for at least 2 weeks after
confirmed with an MRI Reduce all types of
stroke
O Intra cranial atherosclerosis
Goal SBP <140 or <130 in diabetes, LDL
<70, dual antiplatelet therapy with aspirin
and clopidogrel for 90 days & lifestyle
modifications fewer cerebrovascular events
Acute Reduction of BP in ICH is Safe