SGS 11 Drugs Used in TB &

Asthma
Prof Kombara/ Dr Igor/ Dr Aishah
Q1. Regarding the treatment of patients with
pulmonary TB:

A. Monotherapy is adequate to eradicate TB

bacilli
B. Patients are encouraged to roam about for
fresh air.
C. Directly observed-therapy is recommended to
ensure compliance.
D. Therapy may be complicated by adverse drug
reactions.
E. The aim of therapy is to cure, prevent relapse
and transmission of TB.
Q2. First line drugs used in the treatment of
tuberculosis (TB) are:

A. isoniazid
B. streptomycin
C. ethionamide
D. pyrazinamide
E. rifampin
Q3. Isoniazid
A. Acts by inhibiting mycolic acid synthesis.
B. Is usually given parenterally.
C. Metabolism is associated with genetic
variation in the acetylating enzyme.
D. can cause peripheral neuritis in fast
acetylators.
E. doses should be reduced in patient with
chronic liver disease.
Q4. These adverse effects are commonly
associated with the following drugs:

Effect Drug
A. Peripheral neuritis Isoniazid
B. Hepatotoxicity Rifampin
C. Retrobulbar neuritis Pyrazinamide
D. Ototoxicity Ethambutol
E. Nephrotoxicity Streptomycin
Q5. The following statements are regarding
bronchial asthma:

A. It is a chronic respiratory disease.

B. It is characterized by bronchial
hyperreactivity.
C. It is associated with excessive mucus
production.
D. Contraction of bronchial smooth muscle is
reversible with current therapy.
E. Inflammation can be reversed using
bronchodilators.
Q6. Salbutamol
A. Is a short acting beta2-adrenergic agonist.
B. Is normally prescribed for prophylaxis.
C. Can be taken orally or via inhalation.
D. Is used to abort premature labour.
E. can cause palpitations
Q7. Methylxanthine

A. acts by inhibiting phosphodiesterase.

B. is mainly used as an antiinflammatory agent
in the treatment of bronchial asthma.
C. depresses the central nervous system.
D. causes tachycardia.
E. usage requires therapeutic drug monitoring.
Q8. The following drugs have significant anti-
inflammatory action in the treatment of bronchial
asthma:
A. Hydrocortisone
B. Salmeterol
C. Montelukast
D. Cromolyn sodium
E. Ipratropium bromide
Q9. The following are statements regarding the
mechanism and pharmacological action of
corticosteroid in asthma:

A. It inhibits the lipoxygenase pathway.

B. It stimulates the cleavage of arachidonic acid at
the phospholipid layer of cell membrane.
C. It inhibits the infiltration of asthmatic airways by
inflammatory mediators.
D. It potentiates the effects of -receptor agonists.
E. It reduces bronchial reactivity if taken regularly.
Q10. Cromolyn sodium
A. Is a mast cell stabilizer.
B. Inhibits phospholipase A2 at the
phospholipid layer of cell membrane.
C. Inhibits the release of inflammatory
mediators.
D. Is usually used in the management of acute
asthma attack.
E. Is well absorbed when administered orally.
SAQ
 SAQs
Classify drugs used in the treatment of bronchial
asthma (5 mins)

Mechanism of action and side effects of

Theophylline (5 min)