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increased capillary
hydrostatic pressure increased
resistance
incomplete
edema diastolic cardiac
filling hypertrophy
Causes of left ventricular failure
Volume over load: Regurgitate valve
High output status
Pressure overload: Systemic hypertension
Outflow obstruction
Loss of muscles: Post MI, Chronic ischemia
Connective tissue diseases
Infection, Poisons
(alcohol,cobalt,Doxorubicin)
ECHOCARDIOGRAPHY
The Preferred Methods
Helpful in Determining the etiology
Follow Up of Patients Heart Failure
PULMONARY FUNCTIONS
A Little Value in Diagnosis Heart Failure
Usefull in Excluding Respiratory Diseases
EXERCISE TESTING
NUCLEAR CARDIOLOGY
CMR
( CARDIAC MAGNETIC RESONANCE IMAGING)
Coronary Angiography :
in CADs Patients
Haemodynamic Monitoring :
To Assess Diagnostic and Treatment of HF
Endomyocardial Biopsy :
in Patients with Unexplained HF
NATRIURETIC PEPTIDES
Cardiac Function (LV Function )
Plasma Natriuretic Peptide Concentration
(Diagnostic Blood Use for HF)
Natriuretic Peptide :
Greatest Risk of CV Events
Natriuretic Peptide :
Improve Outcome in Patients with
Treatment
If Normal
Assess Presence of Cardiac Disease by ECG, X-Ray Heart Failure
or NatriureticPeptides (Where Available) Unlikely
Tests Abnormal
Tests Abnormal
1. Prevention
a) Prevention and/or controlling of diseases leading
to cardiac dysfunction and heart failure
b) Prevention of progression to heart failure once
cardiac dysfunction is established
2. Morbidity
Maintenance or improvement in quality of life
3. Mortality
Increased duration of life
HYDRALAZINE-ISOSORBIDE DINITRATE
Recommendation
HFSA Guidelines for Management of Patients With Heart Failure Caused by Left
Ventricular Systolic Dysfunction - Pharmacological Approaches 2000
Antiplatelet Drugs
Recommendation
HFSA Guidelines for Management of Patients With Heart Failure Caused by Left
Ventricular Systolic Dysfunction - Pharmacological Approaches 2000
Antiarrhythmics
No indication for the use of antiarrhythmic agents in HF
CLASS I ANTIARRHYTHMICS
should be avoided
CLASS II ANTIARRHYTHMICS
Beta-blockers reduce sudden death in heart failure
CLASS III ANTIARRHYTHMICS
Amiodarone is the only antiarrhythmic drug without
clinically relevant negative inotropic effects.
Asymptomatic LV
Indicated Not indicated Post MI Not indicated
dysfunction
Indicated if
Symptomatic HF (NYHA II) Indicated Indicated Not indicated
Fluid retention
Indicated Indicated
Worsening HF (NYHA III-IV) Indicated Indicated
comb. diuretic
Indicated Indicated
End-stage HF (NYHA IV) Indicated Indicated
comb. diuretic
PREVENTION
IS BETTER THAN
TREATMENT
Thank YoU