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K Siva Prasad
The balance between cell viability and cell
death is critical for all organisms, and involves
a network of proteins and communication
amongst several signalling pathways.
Why ??
Interesting Fact!
Without apoptosis, 2 tons of bone
marrow and lymph nodes and a 16-km
intestine would probably accumulate in a
human by the age of 80
Impaired cell death is associated with various
human pathologies, including
1. Immunodeficiency
2. Autoimmunity
3. neurodegenerative diseases
4. and cancer
Similar to proliferation, cell death is also essential
for embryonic and postnatal development and
for tissue homeostasis.
What is Death ?
In the absence of a clearly defined biochemical
event that can be considered as the point-of no-
return,
APOPTOSIS
NECROSIS
AUTOPHAGY
Life and Death Matter
Autophagy, which has been proposed as a third mode
of cell death, is a process in which cells generate
energy and metabolites by digesting their own
organelles and macromolecules