Human Herpes Virus

Double stranded DNA virus

Envelope,thymidine kinase,DNA po-
lymerase
Lytic,persistent,latent and immor-
talizing infection
 HSV(Herpes Simplex Virus)
Tipe 1 dan 2
structure
Replication
Patogenesis
Immunitas
 Desease
- cause lifelong infection
- recurrent disease is a source of contagion
- may cause asymptomatic shedding
 Transmission
Transmitted in saliva,vaginal secretion and
By contact with lesion fluid
Transmitted orally,sexually and by placement
into eyes and broken skin
HSV-1 generally transmitted orally
HSV-2 by sexually transmitted
 Who is at risk?
Children and sexually active individuals
Physicians,nurses,dentist and others in con-
tact with oral/genital secretionsat risk for
infections of fingers( herpetic whitlow)
Immunocompromised and neonates at risk
 Oral Herpes
Primary herpetic gingivostomatitis
HSV-1 (children)
HSV-2(adult)
Lesion: vesicel ulcerated
palatum,pharyng,gingiva,buccal mucosal and
tounge
 DNA,double stranded,icosahedral,envelope
Encode many protein
Thymidine kinase,DNA polymerasereplicate
a good target for antiviral drugs
 Pathogenesis
Cause direct cytopathologi
Avoid antibody by syncytia sel
Reactivates from latency by stress,imun-
suppression
CMI required for resolution with limited role
for antibody
 Control:
- Acyclovir (anti viral)
- No vacine is available
- Health care workers: wear gloves to prevent
herpetic whitlow
 Text book: medical Mycrobiology
 TERIMA KASIH