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PHARMACOKINETIC AND
BIOAVAILIBILTY IN CLINICAL
SITUATIONS
SUBJECT: BIOPHARMACEAUTICS
4TH YEAR EVENING
JINNAH UNIVERSITY FOR WOMEN
GROUP 11
MEMBERS: MEMBERS: AREEBA, AYESHA, IQRA,
NIDA, OMAMA, SAFIA, SHEEMA, USRA &
ZAHIDA.
ACKNOWLEDGED BY MISS ASMA MONAZZAM.
PHARMACOKINETICS
Pharmacokinetics is the movement of the drug
particles inside the body.
Absorption is the movement of the drug from
the site of administration into the bloodstream.
Distribution is the movement of the drug into
the cells.
Metabolism is the conversion of the drug into
another substance or substances.
Excretion is the removal of the drug
of drugs in an individual patient.
BIOAVAILIBILITY
More than one drug that are two or more medicines can
contend with one another for the same protein- binding site,
which can cause dislocation of the medicine with the inferior
attraction from the required site of the protein. drug interaction
can leads to allosteric or non competitive interaction as a
medicine -induced conformational change in the requisite site
which can cause the disarticulation of the medicine which is in
the bound form
DRUG METABOLISM INDUCTION:
FOR EXAMPLE:
Mechanism of anti coagulant , anti depressant ,
corticosteroids can induce by phenobarbitone therefore the
efficacy of these drug is reduced therefore its effect the
drug kinetics.
INHIBITION OF DRUG ABSORPTION
Various drugs and dietary supplements can
decrease the gastrointestinal tract. Antacids containing
magnesium and aluminum hydroxide often with
absorption of many drugs.