Vindecare functionala a

infectiei HIV
http://www.mdpi.com/1999-4915/2/5/1069/htm
Pacient:
Tratament initial LAM
Primul transplant
Boala grefa contra gazda gradul I

https://jamanetwork.com/journals/jamadermatology/fullarticle/2496380
 Analize de laborator
Genotiparea CCR5 PCR
Himerism complet in ziua 61

http://www.nejm.org/doi/full/10.1056/NEJMoa0802905
 Analizarea fenotipului coreceptorului HIV 2.9%
tropism CXCR4/dual
Raspunsul imun celular si umoral

http://www.nejm.org/doi/full/10.1056/NEJMoa0802905
 Alte analize
Ziua 159 biopsie rectal

Lamina propria reprezint un rezervor pentru

virusul HIV la pacienii n al cror snge nu este
detectabil ARN-ul viral.
S-au gsit macrofage CCR5+
 Evolutia pacientului
Ziua 332 Leucemia recidiveaz
Scade chimerismul
ncepe tratamentul cu Cytarabine i
Gemtuzumab

Ziua 391 Primete un nou transplant de

celule stem CCR5 32/32
http://www.nejm.org/doi/full/10.1056/NEJMoa0802905
Pacientul Berlin
Mississippi baby
Un alt pacient Berlin
Pacientii Boston
Editare genic
Editare genic
 Bibliografie
http://www.nejm.org/doi/full/10.1056/NEJMoa0802905
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287108/
http://www.bloodjournal.org/content/124/3/344?sso-
checked=true
http://www.fredhutch.org/en/news/center-
news/2016/08/can-timothy-ray-browns-hiv-cure-be-
repeated-gary-steinkohl-boston-patient.html
http://www.nejm.org/doi/full/10.1056/NEJM1999052734021
14
https://www.nature.com/news/hiv-overcomes-crispr-gene-
editing-attack-1.19712
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156173/