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Anticholinergic Drugs
Dr. Osama
Adrenergic and
Antiadrenergic Drugs
Prof. Khatab
Quiz?
Major neurotransmitter
released at end organ
effectors of the thoracolumbar
division of the autonomic
nervous system:-
dopamine
adrenaline
noradrenaline
acetylcholine
Quiz?
Preganglionic fibers
terminating on adrenal
medullary chromaffin cells
release:-
a- noradrenaline
b- adrenaline
c- acetylcholine
d- dopamine
Quiz?
Rate-limiting step in
acetylcholine synthesis:-
choline acetyltransferase
activity.
vesicular protein synthesis.
choline uptake.
acetylcholinesterase activity
availability of acetate
2-Storage of Acetylcholine:-
Ach is stored in vesicles.
Vesicular –associated transporter.
Quiz?
Inhibits choline
transport into
cholinergic vesicles:-
bretylium
vesamicol
reserpine
atropine
3-Release
of Ach:-
“excitation –
release
coupling” .
exocytosis
Quiz?
prevention of transmission
agglutination of RBC’s.
Quiz?
Clostridium
toxins inhibit:-
Acetylcholinesterase
prevent reuptake of
choline .
inhibit vesicular
acetylcholine release.
prevent calcium influx
Botulinum
Quiz?
True"
acetylcholinesterase
is found in:-
A- intestine
B-liver
C- erythrocytes
D- plasma
Muscarinic & nicotinic receptors
Muscarinic receptors , 5 subtypes
M1: ‘neuronal’
Excitatory,
Formation of IP3,DAG & Ca++.
Antagonist is pirenzepine
M2: ‘cardiac’.
Inhibitory effect
Openning of K+ channels, of adenylate
cyclase.
Antagonist is gallamine
Cholinergic receptor
type that mediates the
decrease in heart rate
by activating potassium
channels:-
a - M1– muscarinic
b - M2-muscarinic
c -M3-muscarinic
d -nicotinic
Quiz?