Академический Документы
Профессиональный Документы
Культура Документы
Montalban,
RN, US-RN
1. Description of cancer
2. Definition of terms:
- Apoptosis
- Benign
- Carcinogen
- Carcinoma
- Hospice
- Lymphomas
- Leukemia or myeloma
- Malignant
- Metastasis
- Nadir
- Neoplasm
- Sarcoma
- Tumor markers
- Undifferentiated cells
3.Classify cancer.
4. Pathophysiology of cancer cells/theory of pathogenesis
5. Grading and Staging and TNM CLASSIFICATION SYSTEM
6. Elaborate the seven warning signs of cancer .
7. Identify the risk factors.
8. Identify common tumor markers.
9. Identify diagnostic tests.
10. Differentiate benign from malignant neoplasms.
11. Differentiate proliferative patterns from characteristics of a normal
cells.
DESCRIPTION:
- A neoplasic disorder that can involve all body organs
characterized by:
a. Uncontrolled growth and spread of abnormal cells
b. Proliferation: rapid reproduction by cell division
c. Invasion: growth of primary tumor into surrounding
tissue
d. Metastasis: spread or transfer of cancer cells from one
organ or part to another not directly connected.
- Result from a process of altered cell growth and
differentiation which is uncoordinated and lacks
normal regulatory controls over cell growth and
division.
DEFINITION OF TERMS:
apoptosis: program & controlled cell destruction w/c
eliminates damaged, improperly produced & worn out
cells w/out harming the other areas. A normal process
of cell deletion & renewal.
- carcinogen: a physical, chemical, or biological stressor
that causes neoplastic changes in normal cells.
- carcinoma: a new growth or malignant tumor that
originates from epithelial cells, the skin, GIT, lungs ,
uterus, breast and other organs.
- differentiation: a process which normal body cells
have individual characteristics allowing them to
perform different body functions.
- Hospice: a concept of care for terminally ill clients that
includes the idea of intensive caring rather than
intensive care. The family and the client are the focus
of nursing care and the goal is to relieve pain and
facilitate the optimal quality of life.
Lymphomas: neoplasms that originate from the lymphoid
organs.
Leukemia or myelomas: neoplasms that originates from
blood forming organs.
Malignant: term for growth that metastasize and grow;
cancerous lesions that are disordered, uncontrolled
and chaotic proliferation of cells.
Metastasis: the transfer of disease from organ or part to
another not directly connected w/it.
Nadir: the period of time during w/c an antineoplastic
med has its most profound effects on the B.M.
Neoplasm: a new growth, w/c maybe benign or malignant.
Protooncogenes: a normal gene that can become an
oncogene d/t mutation or increased expression.
Oncogene: a gene that has the potential to cause CA;
protooncogenes which is converted via
mutation/chromosomal arrangement.
Sarcomas: neoplasms that originate from muscle, bone,
fat, lymph system, or connective tissues.
Tumor markers: specific bodily subs. that seem to
indicate tumor progression or regression.
Undifferentiated cells: cells that have lost the capacity for
specialized functions.
5 STAGES:
1.) Gap/Growth phase (G1) – time after formation of cell, RNA,
CHON synthesis
2.) Synthesis (S) phase – DNA replication
3.) Gap/Growth phase (G2) – continued RNA & CHON synthesis
4.) Mitosis: cell division: PMAT
- Prophase: chromatin coil shortens forming 2 pairs of
chromatids, centrioles move to opposite end forming a
mitotic spindle
- Metaphase: chromosomes cluster & align midway between
spindle poles
- Anaphase: centromeres divide, divided chromosomes moves
to opposite side of the spindle poles.
- Telophase: chromosome uncoil & become chromatin, nuclear
envelope and nucleoli appear at each daughter cell
5.) Go – cells not yet destined to replicate, ceases at this stage
- Benign & malignant cells display diff. characteristics of
cellular growth, degree of differentiation (anaplasia)
that determines cells malignant potential.
a. hyperplasia: “ increase in the number of cells in a
tissue”; maybe normal/abnormal cellular response.
b. Metaplasia: refers to conversion of 1 type of cell in a
tissue to another type not normal for that tissue – it
results from an outside stimulus affecting parent stem
cells and maybe reversible or progress to dysplasia.
c. Dysplasia: refers to change in size, shape or
arrangement of normal cells into bizarre cells – may
precede an irreversible neoplastic change.
d. Anaplasia: involves a change in the structure of cells
& their orientation to one another, Cx by loss of
differentiation returning to a more primitive form.
e. Neoplasia: refers to abnormal cell growth; maybe
benign or malignant.
Benign: harmless, not infiltrative of other tissues
Malignant: always harmful, may spread or metastasize to
tissues sometimes far removed from the site of origin.
CHARACTERISITIC OF A PROLIFERATIVE CELL/TUMOR
NEOPLASTIC CELLS NEOPLASTIC TUMORS
Appear larger than normal Disorganized, irregular
w/ bigger nuclei nests or sheets or
neoplastic cells
Exhibit uncontrolled Contain high % of
proliferation w/no contact proliferating cells
inhibition.
Serve no homeostatic Some have the ability to
function. metastasize – spread from
the original site to distant
organs.
a.) Solid tumors: associated w/the organs from w/c they
develop, e.g breast or lung CA.
b.) Hematological CA: originates from blood cell forming
tissues e.g. leukemia, lymphoma
RISK FACTORS:
-tobacco
-alcohol
-diet
-reproductive and sexual behavior
-occupation
-pollution
-industrial products
-medicines
-infectious agents
-endogenous hormone
-genetics
PATHOPHYSIOLOGY OF CANCER CELLS:
CARCINOGENESIS
Involves 3 process:
1. Initiation : carcinogens changes the DNA of the cell
causing cell mutation
2. Promotion: repeated exposure to carcinogen resulting to
expression of cellular abnormality or genetic mutation
3. Progression: the expressed ability to invade and
metastasize.
Cell alteration
mutation of protooncogene inactivate tumor
(activate cell proliferation suppressing gene
& differentiation)
Activate oncogene
cell lose control/differentiation
malignant neoplasm
SYMBOL INTERPRETATION
T The extent of the primary tumor
N The absence or presence and extent of regional lymph
node metastasis
M The absence or presence of distant metastasis
T1, T2, T3, T4 Increasing size and/or local extent of the primary tumor
M0 No distant metastasis
M1 Distant metastasis
C A U T I O N UP
C – hange in bowel/bladder habits
A – ny sore that does not heal
U – nusual bleeding or discharge
T – hickening or lump in breast or elsewhere
I – ndigestion
O – bvious change in wart or mole
N – agging cough or hoarseness
U –nusual anemia
P - ain
Benign and Malignant cells DIFFERS in:
Cellular growth characteristics
Method of growth
Rate of growth
Ability to metastasize or spread
General effects
Destruction of tissue
Ability to cause death
Difference Between Benign and malignant
BENIGN MALIGNANT
Cell Well- differentiated Cells are
characteristics cells that resemble undifferentiated
normal cells of the Often bear little
tissue from which resemblance to the
the tumor originated normal cells of the
tissue from which
they arise
1. Weight loss
2. Fever
3. Fatigue
4. Pain
5. Changes in skin
Specific Cancer Signs and Symptoms
BREAST SELF
EXAMINATION
- Cervical CA: early age @ 1st intercourse, multiple sexual
partners, HPV infection (condyloma/warts),smoking
DIAGNOSTIC
EXAMS
Laboratory exams
1. Blood and urine tests
1. Beta-carotene
•sweet potatoes Some green leafy
vegetables like:
• carrots
• cantaloupe •collard greens
• squash • spinach
• apricots • kale
• pumpkin
• mangos
2. Lutein
for healthy eyes is found in green leafy vegetables
such as:
• collard greens
• Spinach
• kale
3. Lycopene
• Tomatoes • apricots
• watermelon • pink
• guava grapefruit
• papaya • blood
4. Selenium ( mineral)
a component of antioxidant enzymes.
Plant foods like:
• rice & wheat
• Brazil nuts contain selenium.
5. Vitamin A
• Liver
• sweet potatoes
• Carrots
• Milk
• egg yolks
• mozzarella cheese.
6. Vitamin C (ascorbic acid)
• fruits and vegetables
• Cereals
• Beef
• poultry and fish.
7. Vitamin E (alpha-tocopherol)
in many oils including:
• wheat germ
• Safflower
• corn and soybean oils
also found in: Mangos, Nuts, & broccoli
a.) Prophylactic surgery: perform w/existing premalignant
condition or known family hx predisposing the person
to CA dev’t.
b.) Curative surgery: all gross & microscopic tumor is
removed or destroyed.
c.) control (cytoreductive): a “debulking” procedure
consist of removing part of the tumor thus decreasing
the number of CA cells, increasing the chance of other
therapies.
d.) Palliative: improve quality of life during survival time;
Done to reduce pain, relieve airway, GIT or urinary tract
obstruction; relieve pressure on the brain or spinal
cord, prevent hemorrhage, remove infected or
ulcerated tumors or drain abscess.
e.) reconstructive or rehabilitative: improve quality of life
by restoring maximal fxn & appearance.
S/E of surgery:
1. Loss of function of a specific body part
2. Reduced function as a result of organ loss
3. Scarring or disfigurement
4. Grieving about altered body image or imposed change
in lifestyle.
- Assignment: Saturday. June 18, 2011
Oligodendroglioma – dendrites
Meningioma – meninges
Medulloblastoma – medulla
Epindydomas - ependymal cells
Astrocytoma - astrocytes