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Functions as biocatalyst
Biocatalyst:
- substrate specific
- reaction specific
- can be regulated in the body
Inorganic catalyst
- resistant to heat
- not specific to certain substr/reaction
- Pt, Zn, H+
Cellular enzymes exist in compartments
E + S ES E + P
2. Koshland
Induced fit model
Enzyme undergoes conformational change
Active site, substrate site, catalytic site
enzyme abnormality
What is enzyme activity?
Vm = maximum velocity
Trypsin ~ pH = 7-8
- E not destroyed.
After release, can react with substrate
- Trypsinogen Trypsin