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Systems
a. Lymphocytes.
3. Lymphoid organs
a. central lymphoid organs
(thymus, bone marrow)
b. peripheral lymphoid
organs (lymph nodes, spleen
and tonsils)
Functions:
Cortex
Capsule
Medulla
Capsule
connective tissue
interlobular septa
Thymic lobules .
Each lobule has a
peripheral dark
zone(cortex) and a
central light
zone(medulla).
Cortex
Cortical lymphoid
sinuses
b.1 Superfacial cortex
Contains lymphoid
nodules and diffuse
lymphoid tissue in
between.
It is mainly populated
by B cells.
When stimulated by
antigen, a lymphoid
nodule responds by
forming a germinal
center.
b.2 Paracortical zone
Diffuse lymphoid
tissue with T cells
( thymus dependent
area ).
Numerous
postcapillary venules
b.3 Cortical lymphoid
sinuses
Include
subcapsular sinus
and
peritrabecular
sinuses .
Contain reticular
cells and fibers,
macrophages and
lymphocytes.
c. Medulla – 2
components
Medullary cords are
lymphoid tissue
cords with many B
cells and plasma
cells.
Medullary lymphoid
sinuses are similar
to the cortical
sinuses.
Functions
postcapillary lymphatic
venules vessels
bloodstream
Significance: to increase the probability
of meeting antigens, distribute
information concerning antigens, and
unite the different parts of the immune
system.
3.b. Spleen
A thick capsule of dense connective tissue,
covered by mesothelium and containing
smooth muscle cells. Trabeculae extend
from capsule into the parenchyma.
The parenchyma is made up of the white
pulp and red pulp.
capsule
trabecula
White pulp
red pulp
Spleen
a. White pulp
Periarterial
lymphatic sheath
Lymphoid nodules
(1) Periarterial lymphatic sheath
Diffuse lymphoid tissue sheath encircling a
central artery.
Mainly contains T cells (thymus-dependent area),
some macrophages.
(2) Lymphoid nodules
Appended to the sheath and rich in B cells.
Have germinal centers when stimulated by
antigens.
(3) Marginal zone
Lies between the white and red pulps,
consisting of many marginal sinuses
The marginal zone harbours an
abundance of blood antigens and thus
plays a major role in the immunologic
activity of the spleen.
Lymphocytes in the white pulp enter the
marginal sinuses to take part in
recirculation.
Marginal
sinuses
White pulp
Red pulp
Marginal
zone
b. Red
pulp
Splenic
Cords
Splenic
Sinus
(1) Splenic cords
a. Diffuse lymphoid tissue organized in
cords, containing B cells, plasma cells.
b. Most capillaries open and pour blood
into the cords, so rich in erythrocytes.
(2) Splenic sinusoids
a. Lined by elongated endothelial cells with
wide spaces between them.
b. Flexible blood cells pass from splenic cords
to the lumen of the sinus.
Functions
Blood filter – removal of aged
erythrocytes and platelets in splenic
cords.
Immune responses – similar to lymph
nodes.
Production of lymphocytes.
Blood storage.
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