PATOLOGI

VULVA

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 Bartholin Cyst
Retention cyst of bartholin gland in labia minora
Can be caused by secundair infection (Neisseria Gonorrheae, very
rare by staphylococus)

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Neoplasma & Premalignant conditions
(Condyloma; Low grade Vulvar Intraepithelial Neoplasia/ VIN I ;
High grade Vulvar Intraepitihelial Neoplasia/ VIN II, III ; carcinoma,
Extramammary Paget Disease, Melanoma vulva)

 Condyloma
- Proposed caused by HPV types 6&11.
HPV transmitted venereally like in penis, around anus

- Condylomata lata : flat lesion, siphilis secundar, rare compared to

Condyloma acuminata : papillary, in all anogenital skin, single or
múltiple, a few milimiter – a few centimeter, pink, koilositosis
(characteristic sign: perinuclear vacuolisation, angular and
pleomorphic nuclei, like HPV infection).

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Whole mount of condyloma acuminatum of vulva
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PATOLOGI
VAGINA

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 Fibroepithelial polyp
 Sarcoma Botrioides

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 Fibroepithelial polyp

- Vaginal polyp, benign, covered by

squamous epithelial, with the polyp stalk
polip consisted of fibrocolagen.
- single, white-grey, < 1cm, simple excision

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Curious mushroom-like appearance of vaginal fibroepithelial polyp.
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Fibroepithelial polyp of vagina showing loose fibrovascular stroma covered by
slightly thickened but otherwise unremarkable squamous epithelium.
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 Sarcoma Botrioides
= Embrional rhabdomyosarcoma.

- Malignant soft tissue tumor, etiology & pathogenesis is unknown

- Soft mass, polypoid, grey, nodular edematous, grapes-like,
with/without per-vaginam bleeding
- Vagina anterior, can be bigger spread to the outside of vagina

- Microskopic: hyperplastic ovoid-spindle cells, myxoid, arranged like

kambium laye, cellular under mucous, eosinophilic cytoplasm, some
with cross striation
- 90 % in babies and children < 5 y
- Can be found in other palces such as urinary bladder & bile duct
- Tumor < 3 cm curable; local excision + chemotherapy.
- Bigger size + invasion > metastases to regional lympnodes,
hematogenous spread

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Botryoid rhabdomyosarcoma of vagina. The grape-like configuration of
this lesion is characteristic.
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Microscopic appearance of embryonal rhabdomyosarcoma. The differential
diagnosis is that of small round cell tumors.
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So-called “cambium layer” beneath non-neoplastic epithelium in
botryoid rhabdomyosarcoma.
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