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Salmonella
• Gram-negative facultative anaerobe bacilli rod-shaped
bacterium belonging to family Enterobacteriaceae
Virulence factors:
fimbriae
- Adherence to GIT
Enterotoxin
- traverse intestinal mucosa
Salmonella
• Somatic O antigen
• Heat stable
• lipopolysaccharide in the outer membrane of the
cell wall
H flagellar antigen
• Heat labile
• Phase I flagellar antigen: specific phase; occur in few strains
determine the immunologic identity of certain serotype
agglutinate only with homologous antisera
4. Carrier state
• Site of chronic carriage: Gallbladder
• Organisms secreted in the feces continuously or
intermittently
Treatment:
antimicrobial therapy
cholecystectomy – remove gallbladder