ANTIMONY

GLUCONATE
PRESENTED BY: HASNAIN SAJJAD(1464)
PRESENTED TO: MAM SHEHLA RAZA
OBJECTIVES:

 Introduction
 Synonyms
 Structure
 Mechanism of action
 Properties
• Physical properties
• Chemical properties
 Side effects
 Uses
INTRODUCTION:
 Sodium stibogluconate is a medication used to treat leishmaniasis. This
includes leishmaniasis of the cutaneous, visceral, and mucosal types.

 Sodium stibogluconate has been studied as early as 1937 and has been in
medical use since the 1940s. It is on the 
World Health Organization's List of Essential Medicines, the most effective and
safe medicines needed in a health system.

 It belongs to the class of medicines known as the “Pentavalent antimonials”.

 Workers in India prepared sodium stibogluconate in the late 1940’s via the
reaction of antimony pentoxide with sodium hydroxide.
Synonyms:

 Antimony sodium gluconate

 Myostibin
 Sodium stibogluconate
 Stibanate
 Stibanose
 Stibatin
 Stibinol
 Stibogluconate de sodium
Structure:
Mechanism of action:

 Sodium stibogluconate is a pentavalent antimonial

which is the drug of choice for kala-azar. The exact
mechanism of action and selective toxicity to the
parasite is unclear.

 The drug inhibits the SH group containing enzymes of

parasite & affects the bioenergetics of the parasite.

 It blocks the glycolytic & fatty acid oxidation pathways.

Physical Properties:
 Average weight:
907.88 g/mol
 Chemical Formula:
C12H35Na3O26Sb2
 Trade Names:
Pentostam and Stiboson
 Routes of administration:
Intravenous and intra muscular
 Legal Status:
Prescription only (UK)
 Molar mass:
910.9 g/mol
Chemical Properties:

 Chemical properties involves following interactions:

The serum concentration of Sodium stibogluconate can

Amodiaquine be decreased when it is combined with Amodiaquine.

The serum concentration of Sodium stibogluconate can

be decreased when it is combined with Chloroquine.
Chloroquine

The serum concentration of Sodium stibogluconate can

be decreased when it is combined with
Hydroxychloroquine
Hydroxychloroquine.

The serum concentration of Sodium stibogluconate can

be decreased when it is combined with Primaquine.
Primaquine
Side Effects:

1. Nausea 
2. Myalgia 
3. Pain at injection site 
4. Cough 
5. Loss of appetite 
6. Headache 
7. Abdominal pain 
8. Tiredness 
9. ECG changes 
10. Anaphylactic shock 
11. Vomiting 
12. Diarrhea
Uses:

 For the treatment of various types of a protozoal

infection called leishmaniasis, which may result from
sandfly bites in tropical and temperate parts of the
world.

 Also investigated for use/treatment in cancer/tumors

(unspecified) and solid tumors.