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Polymers
CO2
&
&
other
H 2O
energy
rich
molecules
Cellular Respiration
C6H12O6 + 6O2 + 36ADP + 36Pi
3 Krebs Cycle
2 ADP
2 PGAL C C C C C C
P P
2 NAD+ 4 ADP
2 NADH 4 ATP
2 Pyruvate C C C
Net:
•2 ATP
•2 NADH
•2 Pyruvate molecules
Balance Sheet for Glycolysis
Input
1 Glucose
2 ADP + Pi
2 NAD+
Output
2 Pyruvate
2 ATP
2 NADH
Transition Reaction
Krebs Cycle
Transition (Citric Acid
Reaction Cycle)
Krebs Cycle (Citric Acid Cycle)
Balance Sheet for the Transition
Reaction and Krebs Cycle
Input Output
2 Pyruvate 6 CO2
2 ADP + 2 Pi 2 ATP
8 NAD+ 8 NADH
2 FAD 2 FADH2
Krebs Cycle
Takes 2 complete
cycles
8 steps, each with
an enzyme
Krebs Cycle 3
Oxidative Phosphorylation
CO2 6
NADH 10
FADH2 2
ATP 4
Electron Transport System
CO2 6
used to make ATP
NADH 10
FADH2 2
ATP 4
Electron Transport System 4
Electron Transport System
+Pi
Electron Transport Chain and
Oxidative Phosphorylation
• Electrons are delivered to O, forming O–
• O– attracts H+ to form H2O
Electron trans-
NADH+H+
Glycolysis Krebs
port chain
cycle
and oxidative
phosphorylation
FADH2
Enzyme
Complex II
Enzyme
Complex I
Enzyme
Complex IV
Figure 24.9
Electronic Energy Gradient
• Transfer of energy from NADH + H+ and
FADH2 to oxygen releases large
amounts of energy
• This energy is released in a stepwise
manner through the electron transport
chain
ATP Synthase
• Two major parts connected by a rod
1. Rotor in the inner mitochondrial
membrane
2. Knob in the matrix
• Works like an ion pump in reverse
Intermembrane space
A rotor in the
membrane spins
clockwise when H+
flows through it down
the H+ gradient.
A stator anchored in
the membrane holds
the knob stationary.
The protruding,
stationary knob
ADP contains three
+ catalytic sites that
join inorganic
phosphate to ADP
to make ATP when
Mitochondrial matrix the rod is spinning.
Figure 24.11
Net ATP Yield ATP
34 to 36 molecules ATP for every
glucose molecule
NAD+
NAD+
NADH
NADH
C C C C C C C C C C C C
(Glycolysis) (Lactic acid fermentation)
Glucose 2 Pyruvate 2 Lactic Acid
Glucose
Anaerobic Aerobic
Respiration Respiration
Pyruvate