KETONE BODIES- AN ALTERNATE

FUEL FOR TISSUES

 INTRO
 SYNTHESISED IN THE LIVER

 DERIVED FROM ACETYL CoA

 ACETONE (VOLATILE), ACETOACETATE

AND β-HYDROXYBUTYRATE
 CAN BE CONVERTED BACK TO ACETYL
CoA AND OXIDISED BY TCA CYCLE

 TRANSPORTED IN THE BLOOD TO

PERIPHERAL TISSUES

 CAN ABLE TO CROSS BLOOD BRAIN

BARRIER
 THEY ARE IMPORTANT SOURCES OF ENERGY
FOR PERIPHERAL TISSUES BECAUSE
A) They are water soluble
B) Synthesized when Acetyl-coA is in
excess
C) They are used in proportion to the
concentration in the blood by
extrahepatic tissues.
 REGULATION
 REGULATED AT THREE LEVELS

1) Factors mobilizing FFA

2) CPT- I
3) Acetyl CoA oxidation