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Introduction
Synthesis
Dopamine receptors
Dopaminergic Pathways
Clinical Uses
Dosage
Adverse Effects
References
Reference:
o Hormones, Epinephrine,
Norepinephrine (other
Catecholamines) are
derived from Dopamine
o Significant role in
learning, goal-directed
behavior, regulation of
hormones, motor control
DA Synthesis and Metabolism
Phenylalanine hydroxylase
L Tyrosine
L Dopa
Dopa decarboxylase
Dopamine ( DA)
D1 - like family:
Includes subtypes D1 and D5
Activation is coupled to G8 ; activates adenylyl cylcase
which leads to increase in concentration of cAMP
D2 - like family:
Includes D2 - D3 – D4
Activation is coupled to G1; inhibits adenylyl cyclase
leading to decrease in concentration of Camp
Also open K channels & closes Ca influx
Dopamine Recptors:
Subtypes Location Function
Mesolimbic Pathway
Mesocortical Pathway
Nigrostraital Pathway
Tuberoinfudibular Pathway
Incertohypothalamic Pathway
Medullary Periventricular
Retinal
Significance of Dopaminergic Pathways:
Mesolimbic Pathway
Associated with pleasure, reward and goal directed to behavior
Mesocortical Pathway
Associated with motivational and emotional responses
Nigrostraital Pathway
Involved in coordination of movement (part of basal ganglia
motor loop/EPS)
Tuberoinfundibular Pathway
Regulates secretion of prolactin by pituitary gland and involved
in maternal behavior
Schizophrenia: