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Depositions
Prof. Ung
Pathology
Year 2
Pathways of abnormal intracellular
accumulations
Liver
• Gross- enlarge, 3 to 6 kg, bright, yellow , soft ,
greasy
• Microscopic- small fat vacuoles in the cytoplasm
around the nucleus,
• Later stage, the vacuoles coalesce to create
clear spaces that displace the nuleus to the cell
periphery
• Fatty cyst
• The significance of fatty change depends on the
cause and severity of the accumulation.
• When it may have no effect on cellular function.
• In the severe form, fatty change may precede
cell death.
• E.g. nonalcoholic steatohepatitis
Pigments
• Pigments are coloured substances that are either
exogenous, coming from outside the body, or
endogenous, synthesized within the body itself.
Exogenous pigment
Lipofuscin pigment
• Wear-and-tear pigment
• Insoluble brownish-yellow granular intracellular
material
• Heart, liver, brain
• Age or atrophy
Melanin
• Brown-black pigment produced in melanocytes
• Epidermis
• Screen against harmful UV radiation
Hemosiderin
• Hemoglobin-derived granular pigment
• Golden yellow to brown
• Local or systemic excess of iron
• Identified by the Prussian blue histochemical reaction
• Local excess
• E.g. common bruise
• Systemic excess
• E.g. hemosiderosis
Pathologic calcification