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H2 antagonists
Decrease acid production
Ranitidine – ZANTAC, RANISAN
Famotidine – FAMOTIDIN, QUAMATEL
Exocrine Pancreatic Insufficiency
Takasidase
Purified fungal (Aspergillus oryzae) enzymes
Digestion of oligosaccharides and
polysaccharides
ORENZYME
Purified animal pancreatin
PANGROL, PANZYTRAT, KREON
Constipation
Lactulose
Disaccharide that draw water into bowel – osmotic action
DUPHALAC
Bisacodyl
Acts by irritating of colon
BISAKODYL-K, FENOLAX
Sodium picosulfate
GUTTALAX, REGULAX
Diarrhea
Cloroxin, nifuroxazid
Antibacterial effects - used in infectious diarrhea including traveler`s diarrhea
ENDIARON
Loperamide
μ opioid receptor agonist – decreasing smooth muscles motility
IMODIUM
Antibiotics
Fusafungine – the only OTC antibiotic
Used as spray for treatment of nasal and throat infection
BIOPAROX
Nasal Preparations (Decongestants)
Applied in nasal spray/drops to relieve nasal
congestion in rhinitis
Vasoconstriction of blood vessels within the nasal
cavity
Should not be taken longer than 3 days in a row
Xylometazoline – OLYNTH
Oxymetazoline – NASIVIN
Tramazoline – MUCONASAL PLUS
Nafazoline – SANORIN
Allergies
Anihistamines
H1 antagonists
Often used to relieve allergic rhinitis (hay fever). Neither loratadine nor
cetirizine are causing sedation
Loratadine
CLARITINE
Cetirizine
ZODAC, ZYRTEC, CETIRIZINE-SANDOZ
Corticosteroids
Beclometazone
OTC products as nasal spray
BECLOMET NASAL AQUA
Vasoprotectives
Bioflavonoinds
Troxerutin – CILKANOL, VENORUTON
Aescin
Saponine isolated from the horse chesnut (Aesculus
hippocastanum)
Induction of endothelial nitric oxide synthesis
AESCIN, YELLON
Analgesics (painkillers) and
antipyretics
Major classes
Paracetamol
Salicylates
Non-steroidal anti-inflammatory drugs
Ibuprofen
Indications include arthritis, dysmenorrhea, fever, migaine and other
conditions with involving inflammation. Investigational (clinical trials) use
include also Alzheimer and Parkinson diseases.
BRUFEN, NUROFEN, IBALGIN
Naproxen
Pain in rheumatic conditions, marketed as relieve in pain of teeth
ALEVE, NALGESIN S
Diclofenac
Treatment of pain of various origin – most commonly in rheumatism. It is
possible to use antipyretic effects but other substances are preferred in fever
Beside oral administration topical use is common
VOLTAREN ACTIGO, VOLTAREN EMULGEL, VERAL, DICLOBENE
Joint, Connective Tissue and
Rheumatism OTC preparations
Other NSAIDs - Indometacin, Ketoprofen, Nimesulide (COX-2)
Combination of enzymes such as trypsin, bromelaine, papain has presumed
anti-inflammatory effect - WOBENZYME
Antidepressants
St. John wort – multiple drug interaction through cytochrome P450 induction
Nootropics
Pirecetam – NOOTROPIL, PIRACETAM, OIKAMID
Lecithin – phosphatidylcholine naturraly occuring in body with presumed
nootropic effects
Vitamin and Mineral Supplements
Online Databases
NobelPLUS – Slovak database of pharmaceutical products:
http://www.nobelplus.sk/
MedlinePlus – service of U.S. National Library of Medicine and National
Institute of Health: http://www.nlm.nih.gov/medlineplus/druginformation.html
Industry Associations
Association of the European Self-Medication Industry: http://www.aesgp.be
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